ID D2GXD5_AILME Unreviewed; 777 AA.
AC D2GXD5;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Villin-1 {ECO:0000256|ARBA:ARBA00017436};
DE Flags: Fragment;
GN ORFNames=PANDA_001552 {ECO:0000313|EMBL:EFB15814.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB15814.1};
RN [1] {ECO:0000313|EMBL:EFB15814.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium tip
CC {ECO:0000256|ARBA:ARBA00004495}. Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Cell projection, microvillus
CC {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}.
CC -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC {ECO:0000256|ARBA:ARBA00008418}.
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DR EMBL; GL192367; EFB15814.1; -; Genomic_DNA.
DR AlphaFoldDB; D2GXD5; -.
DR HOGENOM; CLU_002568_3_1_1; -.
DR InParanoid; D2GXD5; -.
DR GO; GO:0032433; C:filopodium tip; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR CDD; cd11289; gelsolin_S2_like; 1.
DR CDD; cd11292; gelsolin_S3_like; 1.
DR CDD; cd11293; gelsolin_S4_like; 1.
DR CDD; cd11288; gelsolin_S5_like; 1.
DR CDD; cd11291; gelsolin_S6_like; 1.
DR Gene3D; 3.40.20.10; Severin; 6.
DR Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR007122; Villin/Gelsolin.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR PANTHER; PTHR11977; VILLIN; 1.
DR PANTHER; PTHR11977:SF35; VILLIN-1; 1.
DR Pfam; PF00626; Gelsolin; 6.
DR Pfam; PF02209; VHP; 1.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 6.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 4.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 2.
DR SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR PROSITE; PS51089; HP; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273}.
FT DOMAIN 711..777
FT /note="HP"
FT /evidence="ECO:0000259|PROSITE:PS51089"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB15814.1"
FT NON_TER 777
FT /evidence="ECO:0000313|EMBL:EFB15814.1"
SQ SEQUENCE 777 AA; 87014 MW; C25AEFDA08B10C3A CRC64;
IHKTGSSLSY DIHYWIGQAS SQDEQGAAAI YTTQMDDFLK GRAVQHREVQ GNESEAFRGY
FKQGLVIQKG GVASGMKHVE TNSYEVQRLL HVKGKRNVVA GEVEVSWKSF NLGDVFLLDL
GKIIIQWNGP ESNRMERLRG MTLAKEIRDQ ERGGRTYVAV VDGENEKETP KLMEIMNYVL
GQRGSLKAAV PDTVVEPALK AALKLYHVSD SEGKLVVREV ATRPLTQDLL SHEDCYILDQ
GGLKIYVWKG KNASAQERTG AMNQALDFIK AKQYPPSTQV EVQNDGAESA VFQQLFQKWT
LPSWTSGLGK THTLGSVAKV EQVKFDATSM HVQPQVAAQQ KMVDDGSGEV QVWRIEDLEL
VPVDSKWLGH FYGGDCYLLL YTYLIGEKKH YLLYIWQGSQ ATQDEIAASA YQAVILDQKY
NDEPVQIRVP MGKEPPHLMA IFKGRMVVYQ GGTSRANSLE PVPSTRLFQV QGTSSNNTKA
FEVQARASSL NSNDVFVLKT QSCCYLWCGK GCSGDEREMA KMVADTISRT EKQVVVEGQE
PASFWVALGG KAPYASSKRL QEETLAIAPR LFECSNKTGR FLATEIPDFN QDDLEEDDVF
LLDVWDQVFF WIGKHANEEE KKAAAITAQE YLKTHPGGRD PETPIIVVKQ GHEPPTFTGW
FLAWDPFKWS NTKSYEDLKA ELGNSGDWSQ ITEEITSPKL DKFNVNTNLT SGPLPIFPLE
QLVNKSVEEL PEGVDPSRKE EHLSIEDFTK ALGMTPTAFS ALPRWKQQNL KKEKGLF
//
