ID D2H356_AILME Unreviewed; 854 AA.
AC D2H356;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
DE Flags: Fragment;
GN ORFNames=PANDA_004091 {ECO:0000313|EMBL:EFB28854.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB28854.1};
RN [1] {ECO:0000313|EMBL:EFB28854.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR EMBL; GL192457; EFB28854.1; -; Genomic_DNA.
DR RefSeq; XP_002916034.1; XM_002915988.3.
DR AlphaFoldDB; D2H356; -.
DR GeneID; 100472167; -.
DR KEGG; aml:100472167; -.
DR CTD; 6773; -.
DR InParanoid; D2H356; -.
DR OrthoDB; 7823at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10373; SH2_STAT2; 1.
DR CDD; cd16846; STAT2_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR022756; STAT2_C.
DR InterPro; IPR035854; STAT2_SH2.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF41; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12188; STAT2_C; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 572..678
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT NON_TER 854
FT /evidence="ECO:0000313|EMBL:EFB28854.1"
SQ SEQUENCE 854 AA; 97547 MW; 093490D0F08C3D32 CRC64;
MAQWEMLQNL SNPFQDQLHQ LYSESLLPMD IRQCLAVWIE DQNWQEAALG NDDSKATVLF
FHFLDQLNNE CGRCSQDPDL LLLQHNLRKF SRDVQAFPQG PTQLAEMIFN LLLEEKRILI
QAQRAQLEQG EPALEAPVES QQHEIESRIL ELKTMMEVLV KSISQLKDQQ DVFCFRYKTQ
AQVKTLSLDP HQTRQRQLLQ ETLNELDKRR KEVLDTTKAL LGQLTTLVEL LLPKLEEWKV
QQQKACIGAP LDAGLEQLEK WFTAGARLLF HLRQLLKELG GLSRLVSYKD DPLTTGVDLR
KAQVTELLQH LLQRAFVVET QPCMPQTPHR PLILKTGSKF TVQARLLVRL QEGSESLTAE
VSIDRNPPQS QGFRKFNILT SNQKTLTPEK GQSQGLIWDF GYLTLVEQRS GGSGKGCNKG
MLGVTEELHV IGITLNYTYQ GLKQELRTDT LPVVIISNMS QVSIAWASVL WFNLLSSNPQ
NQQFFSNPPR APWSLLGPAL SWQFSSYVGR GLDPDQLSML RNKLFGQNSR TEGASLSWAD
FTKRESPPGK LPFWTWLDKI LELVHDHLKD LWNDGRIMGF VSRSQERKLL KKTISGTFLL
RFSETSEGGI TCSWVEHQDD DRVLIYSVQP FTKEVLQSLP LTKIIRHYQL LTDENIPENP
LCFLYPRIPR DEAFGRYYQE KVNLEEQRKY LRQKLIVVSN RQVDELQQPP DLKLEPEAES
FELESGLAPL LQLEPGLELE PLLEAGLNLG PALEPLLEPA LDVARRVSEP DVGPELKLEP
ILDPASQAVP EPDLPHDLRH LNTEEMEIFR NSMKIEEIML NGDPLFAGQN TVDEAYTFHP
SHFCTDGPLI PSDY
//
