ID   D2H618_AILME            Unreviewed;       333 AA.
AC   D2H618;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   06-MAR-2013, entry version 22.
DE   RecName: Full=Gap junction protein;
DE   Flags: Fragment;
GN   Name=GJA4; ORFNames=PANDA_005388;
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2]
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which
CC       materials of low MW diffuse from one cell to a neighboring cell
CC       (By similarity).
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the connexin family.
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DR   EMBL; ACTA01041214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GL192519; EFB25019.1; -; Genomic_DNA.
DR   RefSeq; XP_002917182.1; XM_002917136.1.
DR   Ensembl; ENSAMET00000020378; ENSAMEP00000019609; ENSAMEG00000018550.
DR   GeneID; 100463645; -.
DR   KEGG; aml:100463645; -.
DR   GeneTree; ENSGT00700000104079; -.
DR   HOGENOM; HOG000231127; -.
DR   KO; K07613; -.
DR   OMA; RGALMGT; -.
DR   GO; GO:0005922; C:connexon complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001568; P:blood vessel development; IEA:Compara.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002263; Connexin37.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   PANTHER; PTHR11984:SF17; PTHR11984:SF17; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   Pfam; PF10582; Connexin_CCC; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01134; CONNEXINA4.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   3: Inferred from homology;
KW   Cell junction; Cell membrane; Complete proteome; Gap junction;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   NON_TER     333    333
SQ   SEQUENCE   333 AA;  37478 MW;  77DDD7E9B661ACC9 CRC64;
     MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS DFECNTAQPG
     CTNVCYDQAF PISHIRYWVL QFLFVSTPTL VYLGHVIYLS RREERLRQKE GELRALPAKD
     PRVERALAAI ERQMAKISVA EDGRLRIRGA LMGTYVASVL CKSVLEAGFL YGQWRLYGWT
     MEPVFVCQRA PCPYLVDCFV SRPTEKTIFI IFMLVVGLIS LVLNLLELVH LLCRCLSRGM
     KARQGQDAPP TPRTSSEPYA DQVFFYLPMG EGPSSPPCPT YNGLSSSEQN WANLTTEERL
     ASSRAPLFLD PPPENGQKSP SRPSSSASKK QYV
//