ID D2H7R4_AILME Unreviewed; 1016 AA.
AC D2H7R4;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
DE Flags: Fragment;
GN ORFNames=PANDA_006213 {ECO:0000313|EMBL:EFB17993.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB17993.1};
RN [1] {ECO:0000313|EMBL:EFB17993.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
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DR EMBL; GL192565; EFB17993.1; -; Genomic_DNA.
DR RefSeq; XP_011221457.1; XM_011223155.2.
DR AlphaFoldDB; D2H7R4; -.
DR STRING; 9646.ENSAMEP00000005466; -.
DR eggNOG; KOG2710; Eukaryota.
DR HOGENOM; CLU_010134_1_0_1; -.
DR InParanoid; D2H7R4; -.
DR OMA; RQPIRHK; -.
DR OrthoDB; 25176at2759; -.
DR TreeFam; TF332212; -.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04394; RhoGAP-ARHGAP11A; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR042869; ARHGAP11A/B.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15670; RHO GTPASE ACTIVATING PROTEIN 11A; 1.
DR PANTHER; PTHR15670:SF4; RHO GTPASE-ACTIVATING PROTEIN 11A; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1016
FT /note="Rho-GAP domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015088235"
FT DOMAIN 49..239
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 298..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1016
FT /evidence="ECO:0000313|EMBL:EFB17993.1"
SQ SEQUENCE 1016 AA; 112744 MW; 98478D447B5CFCE5 CRC64;
MWDRRLVRLA LLQQLRAVYG IKVKSGRGQC DRRRHETAAT EIVGKIFGVP FNALPHSVVP
EYGHIPSFLV DACTSLEEHI HTEGLFRKSG SVIRLRALKN KLDHGESCLS SAPPCDVAGL
LKQFFRELPE PILPADLHEA LFKAQQLGTE EKNKATLLLS CLMADHTIDV LRYFFNFLRN
VSLRSSENKM DSSNLAVIFA PNLLQTSEGH EKMSANTEKK LRLQAAVVQT LIDYASDIGH
VPDFIQEKIP AMLGLDGLCA TPSLEGFEEG ECETPGDFKR RQRQSVGDFV SGALNKLKSN
RTPSVTPQQE KNAQVSISPT ILTPNAKRKL PVDSSHGFSS KKRKSIKHSF NFELLPTNLF
SSSSTPVSVP FDTSPEGSSQ SSLSPVAISG NHLISTGVLR RSKRIASKKV CRVESGKAGC
FSPKISRKEK VRRSLRLKFS LGKSSKDING CSGVDRYENV GRRLANQQSL KNRIESVKTG
LLFSPDIDER LTKKGSKKIS KSEENLLTPE RLDGTSYRMS WTGPSSSSFQ ERAANEASPI
NRNLEVENSL EPDTTVEKSP VSSYEFTPTN IHDKHNNNVT GSSLSGDENN LTTETLVKIQ
KAFSESGSNL HALVNHRQSS ITNVGKLKLN ETSSIEYSPE KNLFETNDLT VIESNEHQTT
TDENSFSEQD ISHQTQKLDR EAIITCYSAH TIEHEKSIHS NIPRDHSVKP ELPSDEHIKK
PQSPRDKLNP LLKESENMIE ENLLKCAASR EHEADTSTSG QITGDITNLP RPRPVRIVQQ
QSLVETCHTA SSESLQTTEH GRVSDHIQWF NRLSLNEPNR TKVRSPLKFQ RTPVRQSVRR
INSLLEYSRQ PVRHKLEGLG DAASPLVKSV SCDSALSSAI ESTSKDSLMS CTKSGPKEQK
VTACEVPYDA ISKSGMELTY KSFSKVRRHP DSKNASLGST RVCKQEVVSD GQIKVPLDDL
TNHDILKSVV NNNTGPGINT RVLRKPSEKE RVWYKGSPKN PIGKAQLLPT SKPVDL
//
