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Database: UniProt
Entry: D2H9J8_AILME
LinkDB: D2H9J8_AILME
Original site: D2H9J8_AILME 
ID   D2H9J8_AILME            Unreviewed;       874 AA.
AC   D2H9J8;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   20-DEC-2017, entry version 45.
DE   SubName: Full=N-deacetylase and N-sulfotransferase 3 {ECO:0000313|Ensembl:ENSAMEP00000012163};
DE   Flags: Fragment;
GN   Name=NDST3 {ECO:0000313|Ensembl:ENSAMEP00000012163};
GN   ORFNames=PANDA_006999 {ECO:0000313|EMBL:EFB18194.1};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB18194.1};
RN   [1] {ECO:0000313|EMBL:EFB18194.1, ECO:0000313|Ensembl:ENSAMEP00000012163}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000012163}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; ACTA01059626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01067626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01075626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01083626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01091626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01099626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01107626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01115626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01123626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GL192600; EFB18194.1; -; Genomic_DNA.
DR   RefSeq; XP_002918534.1; XM_002918488.3.
DR   STRING; 9646.ENSAMEP00000012163; -.
DR   Ensembl; ENSAMET00000012681; ENSAMEP00000012163; ENSAMEG00000011533.
DR   GeneID; 100484094; -.
DR   KEGG; aml:100484094; -.
DR   eggNOG; KOG3703; Eukaryota.
DR   eggNOG; ENOG410XQN4; LUCA.
DR   GeneTree; ENSGT00760000119023; -.
DR   HOGENOM; HOG000008010; -.
DR   KO; K02578; -.
DR   OMA; TVIHDLG; -.
DR   OrthoDB; EOG091G02CP; -.
DR   TreeFam; TF313193; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:Ensembl.
DR   GO; GO:0042328; F:heparan sulfate N-acetylglucosaminyltransferase activity; IEA:Ensembl.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   GO; GO:0015014; P:heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; IEA:Ensembl.
DR   InterPro; IPR021930; Heparan_SO4_deacetylase.
DR   InterPro; IPR037359; NST/OST.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR10605; PTHR10605; 1.
DR   Pfam; PF12062; HSNSD; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     15     34       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       20    507       HSNSD. {ECO:0000259|Pfam:PF12062}.
FT   DOMAIN      597    846       Sulfotransfer_1. {ECO:0000259|Pfam:
FT                                PF00685}.
FT   NON_TER     874    874       {ECO:0000313|EMBL:EFB18194.1}.
SQ   SEQUENCE   874 AA;  101152 MW;  632778D295E8FB99 CRC64;
     MSFIMKLHRH FQRTVVLLAT FCMVSIIISA YYLYSGYKQE NEPSEMMSEV DCGDFQHLPY
     RLVEVKAMKL SDASRTDPTV LVFVESQYSS LGQDIIMILE SSRFQYHIEI APGKGDLPAL
     TEKMKGKYIL IIYENILKYI NMDSWNRSLL DKYCVEYGVG VIGFHKSSEK TLQSFQLKGF
     PFSIYGNLAV KDCCINPHSP LLHVTKSSKL EKGSLPGTDW TVFQINHSAY QPVIFAKVKT
     PENLSPPPIS KGAFYATVIH DLGLHDGIQR VFFGNNLNFW LHKLIFIDAV SFLSGKRLTL
     SLDRYILVDI DDIFVGKEGT RMNTNDVKAL LDTQNLLRAQ ITNFTFNLGF SGKFYHTGTE
     EEDEGDDHLL GSVDEFWWFP HMWSHMQPHL FHNESSLVEQ MILNKKFALE HGIPTDMGYA
     VAPHHSGVYP VHVQLYEAWK KVWNIRITST EEYPHLKPAR YRRGFIHKNI MVLPRQTCGL
     FTHTIFYKEY PGGPKELDKS IQGGELFFTV VLNPISIFMT HLSNYGNDRL GLYTFVNLAN
     FVQSWTNLRL QTLPPAQLAH KYFELFPDQK DPLWQNPCDD KRHRDIWSKE KTCDRLPKFL
     VIGPQKTGTT ALYLFLVMHP SIFSNSPSPK TFEEVQFFNR NNYHRGIDWY MDFFPVPSNV
     TTDFLFEKSA NYFHSEEAPK RAASLVPKAK IITILIDPSD RAYSWYQHQR SHEDPAALKF
     SFYEVISAGP RAPSELRALQ KRCLVPGWYA SHIERWLVYF PPFQLLIIDG QQLRMDPATV
     MDEVQKFLGV SPHYNYSEAL TFDSHKGFWC QLLEEGKTKC LGKSKGRKYP PMDPDSREFL
     SSYYRDHNVE LSKLLHRLGQ PLPSWLRQEL QKVR
//
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