ID D2HA62_AILME Unreviewed; 4155 AA.
AC D2HA62;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=PKHD1 like 1 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=PANDA_007271 {ECO:0000313|EMBL:EFB25669.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB25669.1};
RN [1] {ECO:0000313|EMBL:EFB25669.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
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DR EMBL; GL192620; EFB25669.1; -; Genomic_DNA.
DR InParanoid; D2HA62; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 12.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 14.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR011658; PA14_dom.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR46769:SF2; FIBROCYSTIN-L; 1.
DR PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF07691; PA14; 1.
DR Pfam; PF01833; TIG; 14.
DR SMART; SM01225; G8; 2.
DR SMART; SM00429; IPT; 12.
DR SMART; SM00758; PA14; 1.
DR SMART; SM00710; PbH1; 10.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF49503; Cupredoxins; 1.
DR SUPFAM; SSF81296; E set domains; 14.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51820; PA14; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 319..476
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 2170..2290
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT DOMAIN 3022..3160
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB25669.1"
FT NON_TER 4155
FT /evidence="ECO:0000313|EMBL:EFB25669.1"
SQ SEQUENCE 4155 AA; 456806 MW; 916365384F79487C CRC64;
SDGSKIIPKV TEIIPKYGST NGATRLTIKG EGFAQANQFN YGVGNAELGN SVQLVSSFRS
IACDVEKDSS HSTQITCYTR AMPEDSYNVK VSVDGVPITE SNTCRGRINS WECTFNAKSF
RTPMIKSITP LSGTPGTLIT IQGRIFTDVY GSNTALSSNG KNVRILRVYI GGMPCELLIP
QSDNLYGLKL DHPNGDMGSM ICKTTGTYIG HHNVSFILDS DYGRSFPQKM AYFVSSLNKI
SMFQTYAEVT MISPSRGSIQ GGTMLMISGR FFDQTDFPVR VLIGGQACDI LNVTENSICC
KTPPKPEVLR TVYPGNHTTG GRGLKLEVWN NSRPVHLEEI LEYNEKTPGY LGASWVDSTS
YIWPMEQDTF VARFSGFLVA PDSDVYRLYI KGDDRYAMYF SQTGHPKDKV RIAYHSSNAN
DYFSSPTQRS DDIYLQKGKE YYIEILLQEY RLSAFVDVGL YQHRNVYTEQ QTEDAVNEEQ
VIRSQSTIVQ EVQVITFENW ETSSATNEVQ KITVTSPCVE ANSCSRYQYR LTYNMEKTVL
LPGDASDFIL QSALNDLWSI KPDTVQVIRT QNPQSYVYVV TFISTRGDFD LLGYEVFEGD
NVTLTITEQI KGKPSLDTFT LNWDGITSKP LTPWSSEAEF QAAVEEMVTA KCPPQIANFE
EGFVVKYFRD YETDFNLEHI NRGKKTAETD AYCGRYSLKN PAVLFDSADV KPNRLPYGDI
LLFPYNQLCL AYKGFLANSI ALKFQYQDRS KVTRSNDIQF TYNFTNGNKW TYTCIDLLDL
IQTKYTGTNF SLQRIGFQKA AESQSFYVDA VYIGQTSTVS VWDEKPKRRL PALANKGIFL
KHFQVNHTKI NGSSMANQYS ITMTSYNCSY NIPMMAVSFG QIITNETENE SVYRGSNWPG
ESKIRIQRIQ AASPPLSGSF DIQAYGHILK GLPATASAPD LQFALQSVEE VGRVSVTREG
TCSGYSWNIK WRSRCGKQNL LQVNDPNILG EKANMTVVKI KEGGLFRQRI LGDLLRTPSQ
QPQVEVYVNG IPAKCSGDCG FTWDPMATPL VRAINPSQGS YEKSAILTIS GSGFSPDSAL
SVSVGPMGCS LLSVDENEIK CQILNGSAGH FPVAVSVAGV GLARNVGAEV FYFTYQNRIS
HIWPASGSLA GGTLLTVTGF GFNENSKVLV ANETCNVIEG DLNKITCRTP KRIEGTVDIS
VITSGFQATA KDAYSYNCLQ TPVVTDFSPK VRTIQGEVNL TIKGYNFGNE LTQNVEVYVG
GKPCQIFQWN FTGIRCLLPK LSPGKHDIHV EVRNWGFAST RDKLNASIQY VLEVTAMYPQ
RGSLYGGTEI TIMGLGFSTI PTENTVLLGS FPCDVISSSE NVIKCILRST GNTFSITNTG
EDSVHGLGYA WSPSVLNVSV GDTVTWRWQA HPFLRGMGYR VFSVSSPGSV IYDGKGFTNG
REKSASGSFS YQFTSPGIHY YSSGYVDEAH STFLQGVIKV LPAETRHIPL HLFVGSTEAT
YARVLLPKGP VNLHLGSSVA GCLATEPLCG PNNTRVTNSD GLVFELSSCF SPSINNISPS
AGILNELITI TGHGFSNLTC ANKVTIGNYP CIVEESSYNS IICHIDPQNS MDVGIREIVT
LTVYNLGTAI NTPSNEFDRR FVLLPNIDTV LPHAGSTTGM TRVTIKGSGF AVSSAGVEVF
MGHFPCKVLS VNYSAIECET SPAPQQPVKV DLLVHGVPAQ CQGDCSFSYL ESITAFVTRI
FPNSVEGPVK VLIEGDGFGT ILEDIAVFIG NQQFRAIDVN ENNITVLVSP LPAGLHSLSV
VVGSKGLALG NLTVSSPAVA SITPTSGSIA GGTTLVITGN GFYPGNTTVT VGDEPCEIFS
VNSSEVCCCT PAGTAGRVSV KIFVNAVAYP PLSFTYTLED TPLLRELVPN TGPPGTKIQI
TGSNFGIDIL DISVMIDNIP CNVTMVNDSV LQCTTGDHAG GTFPVTMLHK TKGFAVSTVV
FEYPLAIQNI HPSQGSFGGG QTMTVTGIGF NPQTSIILVC GSECAVDRLK SDCTTLLCQI
PRNDGRGPEQ ACEVSVVNGK DLSQSTTPFT YTMLLTPLIT EIYPKRGSTA GGTRLTITGS
GFSENMQDVL ITIAKAKCDV EYSNKTYIIC MTNAHISSGW APVHVSIRSM GMARLDDSDF
LYVDAWSSNF SWGGKSPPEE GSLVVITKGQ TILLDQNTPI LKMLLIQGGT LIFDEADIEL
QAENILITDG GILQIGTEAS PFQHRAVITL HGHLRSPELP VYGAKTLAVR EGILDLHGLP
VSVIWTRLAH TAKAGERTLI LQEVVTWKPG DKIVIASTGH RHSQRENEKR TIASVSADGT
KIILTTPLDH THLGITVTLP DGTLFEARAE VGILTRNILI RGSDNVEWSN KIPACPDGFD
TGEFATQTCF QGKFGEEIGS DQFGGCIMFH APIPGANMVT GRIEYVEIFH AGQAFRLGRY
PIHWHLLGDL QFKSYVRGCA IHQAYNRAVT IHNTHHLLVE WNIIYDIKGG AFFIEDGIEH
GNILQYNLAV FVQQSTSLLN DDVTPAAFWV TNPNNTIRHN AAAGGTHFGF WYRMNNHPDG
PSYDRNICQK RVPLGEFFNN TVHSQGWFGM WIFEEYFPMQ TGSCTSTVPV PAIFNSLTTW
NCEKGAEWVN GGALQFHNFV MVNNFEAGIE TKRILAPYVG GWGETNGAVI KNAKIVGHLD
ELGMGSAFCT SKGLVLPFSE GLTVSSVHFM NFDRPSCVAL GVTSITGVCN ERCGGWSAKF
VDIQYFHTPN KAGFRWEHEA VLIDVDGSLT GHRGHTVIPH SSLLDPSHCT QEAEWSIGFP
GAVCDASVSF HRLAFNKPSP VSLLEKDVVL SDSFGTSIVP FQKKRLTHMS GWMALIPNAK
HINWYFKDVD HITNISYTST FYGFKEEDYV IISHNFTQNP DMFNVIDMRN GSSNPLSWNT
SKNGDWHLEA NTSTLYYLVS GRNELQQSQP ISGTLDPDVK DVIINFQAYC CLLQDCFPVH
PPSRKPIPRK RPATYNLWSN DSFWQSSREN NYTIPHPGAN VVIPEGTWVV ADIDIPPMES
LVIWGVLELE DKHSVGAAES SYRKVVLNAT YISLQGGRLI GGWEDNPFKG ELQIILRGNH
STPEWTLPEG PNQGSKVLGV FGELDLHGIP RSVYKTKLSE TAEAGSKVLS LMDAVDWQEG
EEIVITTTSY DFYQTETRSI IKILHDQKIL ILNDTLSYTH LAERYHAPGT GQSYTLAADV
GILSRNIKIL GEDYPGWFKE SFGARVLVSS FTQNMRKFKG NARISNVEFY HSGQEAFRDS
TDPRYAVTFL NLGQIQEHGS SFIRGCAFHN GFSPAIGVFG TDGLDIDDNI IHFTVGEGIR
IWGDANRVRG NLVVLSVWPG TYQNRKDLSS TLWHAAIEIN RGTNTVLQNN VVAGFGRVGY
RIDGEPCSNQ SNPMEKWFDN EAHGGLYGIY MNQDGLPGCS LIQGFTIWKC WDYGIYFQTT
ESVRIYNVTL VDNGMAISSM IYMPAAVSHK ISSKTVKIKS SLIVGSSPGF NCSDVLTNDD
PNIELSAAHR SARPPSGGRS GICWPTFASA HNMAPRKPHA GLMSYNAISG LLDISGKFKH
SSTFVGFKNV CSGETNVIFI TNPLNEDLQH PIHVKDIQLV DTTEQSKIFI HRPDISKVNP
ADCVDMVCDA KRKSFLRDMD GSFLGNSGSV IPQAEYEWNG NSQFGIGDYR IPEVMLTFPN
GSRIPVTEKA PRKGIIRDST CKYIPQWQSY RCFGMEYAMM AIESLDSDTE TRRLSPVAVV
SDGYVDLING PQDHGWCAGY TCQRRLSLFH SIVALDKSYE IYFTGTSPQN LRLVLLNVDH
KKAVVVGIFF PTFQRLDVYV NNALVCPKNT VWNPQQKYCE LNRHLYTEQF LPNLNSTVLG
ENYFDRTYQM LYLLVKGTIP VEIHTTAVIF VSFQLPAVTE DDFYSSHNLV RNLALFLKIP
SDKIRVSRII QGDSLRRKRS TGLTVALEIG DAPLQFLSDG TAGQMQLTEL QKIADSLGQA
IISGKTSSIL GFNISFMSIT DPIPSPSDSA WIKVTAQPVE RFAFPVHHVA FVSSLSVITQ
PVAAQPGQPF SQQPSVKAVD SDGNCVSVGI TSLTLKARLK DSNNNQISGL SGNTTIPFSS
CWANYTDLTL LRTGE
//
