ID D2HEX6_AILME Unreviewed; 1595 AA.
AC D2HEX6;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Clathrin heavy chain linker core motif domain-containing protein {ECO:0000259|Pfam:PF09268};
DE Flags: Fragment;
GN ORFNames=PANDA_009385 {ECO:0000313|EMBL:EFB29366.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB29366.1};
RN [1] {ECO:0000313|EMBL:EFB29366.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00004277}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004277}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004277}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535}.
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DR EMBL; GL192766; EFB29366.1; -; Genomic_DNA.
DR InParanoid; D2HEX6; -.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF6; CLATHRIN HEAVY CHAIN 2; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 5.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 317..340
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB29366.1"
FT NON_TER 1595
FT /evidence="ECO:0000313|EMBL:EFB29366.1"
SQ SEQUENCE 1595 AA; 181413 MW; DAEBB9900C8595A7 CRC64;
LQNLGINPAN IGFSTLTMES DKFICVREKV GEQAQVVIID MSDPMAPIRR PISAESAIMN
PASKVIALKA GKTLQIFNIE MKSKMKSHTM AEEVIFWKWV SVNTVALVTE TTVYHWSMEG
DSQPVKMFDR HASLAGCQMI HYRTDEYQKW LLLIGISAQQ NRVVGAMQLY SVDRKVSQPI
EGHAAAFAEF KSEGNAKPAT LFCFAVRSPT GGKLHIIEVG QPAAGNQPFV KKAVDVFFPP
EAQTDFPVAM QIGAKHGVIY LITKYGYLHL YDLESGVCIY MNRISADTIF VTAPHEPTSG
IIGVNKKGQV LSICVEEDNV VNYATNVLQN PDLGLRLAIR SNLAGAEELF VRKFSTLFAQ
GSYAEAAKVA ASAPKGVLRT SDTVRKFQSI PAQPGQASPL LQYFGILLDQ GQLNKLESLE
LCRPVLQQGR KQLLEKWLKE DKLECSEELG DLVKTADPTL ALSVYLRANV PSKVIQCFAE
TGQFQKIVLY AKKVGYVPDW IFLLRSVMRI SPDQGLQFSQ MLVREEEPLA NIDQIVDVFM
ENSLIQQCTS FLLDALKNNL PAEGHLQTRL LEMNLIHAPQ ANAILGNQMF THYDRAHIAQ
LCEKAGLLQR ALEHYTDLYD IKRAVVHTHL LNPEWLVSFF GSLSVEDSLA CLHALLSASI
RQNLQLCVQV ASKYHEQLGT QSLVELFESF KSYEGLFYFL GSIVNFSQDP DVHLKYIQAA
CKTGQIKEVE RICRESNCYN PERVKNFLKE AKLTDQLPLI IVCDRFDFVH DLVLYLYRNN
LQKYIEIYVQ KVNPSRIPAV VGGLLDVDCS EEVIKNLIMV VRGQFSTDEL VAEVEKRNRL
KLLLPWLESR SHEGCEEPAT HNALAKIYID SNNSPERFLR ENAYYDSRVV GRYCEKRDPH
LACVAYERGQ CDLELIKVCN ENSLFKSEAR YLVHRKDPEL WAHVLEETNP ARRQLIDQVV
QTALSETQDP EEVSVTVKAF MTADLPNELI ELLEKIVLDN SVFSEHRNLQ NLLILTAIKA
DRTRVMDYIS RLDNYDAPDI ANIAVSSALY EEAFAIFRKF DVNASAVQVL IEHIGNLDRA
YEFAERCNEP AVWSQLARAQ LQKDLVKEAI DSYIRADDPS SYLEVVQAAS RSNNWEDLVK
FLQMARKKGR ESYIETELIF ALAKTGRLSE LEDCINGPNN AHIQQVGDRC YEEGMYEAAK
LLYSSVSNFA RLASTLVHLG EYQAAVDSSR KANSTRTWKE VCFACVDGQE FRLAQLCGLH
IVIHADELEE LIRYYQDRGY FEDLISLLEA ALGLERAHMG MFTELAILYS KFKPQKMPEH
LELFWSRVNI PKVLRAAEQA HLWAELVFLY DKYEEYDNAV LTMINHPTDA WREGQFKDVI
AKVANVELYY KALQFYLDYK PLLINDLLLV LAPRLDHTRT VGFFSKAGQL PLVKPYLRSV
QSHNNKSVNE ALNQLLTEEE DYQGLRASID AYDNFDNIAL AQRLEKHQLI EFRRIAAYLY
KGNNRWAQSV ELCKKDRLYK DAMQHAAESR DAELAEKLLQ WFLEEGKREC FAASLFTCYD
LLPPDVVLEL AWRHNLVDLA MPYFIQVMRE YLNKV
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