ID D2HIF1_AILME Unreviewed; 1307 AA.
AC D2HIF1;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 13-SEP-2023, entry version 80.
DE RecName: Full=SOS Ras/Rho guanine nucleotide exchange factor 2 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=PANDA_010977 {ECO:0000313|EMBL:EFB19009.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB19009.1};
RN [1] {ECO:0000313|EMBL:EFB19009.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
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DR EMBL; GL192881; EFB19009.1; -; Genomic_DNA.
DR HOGENOM; CLU_002744_0_0_1; -.
DR InParanoid; D2HIF1; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF150; SON OF SEVENLESS HOMOLOG 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 170..360
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 413..516
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 567..711
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 750..989
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 990..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1048..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1161
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1197
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1259..1279
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB19009.1"
FT NON_TER 1307
FT /evidence="ECO:0000313|EMBL:EFB19009.1"
SQ SEQUENCE 1307 AA; 150049 MW; 64CDD7E293A6600B CRC64;
KVQEQVHPNL SANEESLYYI EELIFQLLNK LCMAQPRTVQ DVEERVQKTF PHPIDKWAIA
DAQSAIEKRK RRNPLLLPVD KIHPSLKEVL GYKVDYHVSL YIVAVLEYIS ADILKLAGNY
VFNIRHYEIS QQDIKVSMCA DKVLMDMFDQ DDIGLVSLCE DEPRSSGELN YYDLVRTEIA
EERQYLRELN MIIKVFREAF LSDRKLFKPS DIDRIFSNIS DIHELTVKLL GLIEDTVEMT
DESSPHPLAG SCFEDLAEEQ AFDPYETLSQ DILSPKFNEH FSKLMARPAV ALHFQSIADG
FKEAVRYVLP RLMLVPVYHC WHYFELLKQL KACSEEQEDR ECLNQAITAL MNLQGSMDRI
YKQYSPRRRP GDPVCPFYNR QLRSKHLAIK KMNEIQKNID GWEGKDIGQC CNEFIMEGPL
TRIGAKHERH IFLFDGLMIS CKPNHSQSRL PGYSSAEYRL KEKFVMRKIQ ICDKEDTCEC
KHAFELVSKD ENSIVFAAKS AEEKNNWMAA LISLHYRSTL DRMLDSVLLK EENEQPLRLP
SPEVYRFVVK DSEENIVFED NLQSRSGIPI IKGGTVVKLI ERLTYHMYAD PNFVRTFLTT
YRSFCKPQEL LSLLIERFEI PEPEPTEADK LAVEKGEQPI SADLKRFRKE YVQPVQLRIL
NVFRHWVEHH FYDFERDLEL LERLESFISS VRGKAMKKWV ESIAKIIKRK KQAQANGISH
NITFESPPPP TEWHISRPGQ FETFDLMTLH PIEIARQLTL LESDLYRKVQ PSELVGSVWT
KEDKEINSPN LLKMIRHTTN LTLWFEKCIV EAENFEERVA ILSRIIEILQ VFQDLNNFNG
VLEIVSAVNS VSVYRLDHTF EALQERKRRI LDEAVELSQD HFKKYLVKLK SINPPCVPFF
GIYLTNILKT EEGNNDFLKK KGKDLINFSK RRKVAEITGE IQQYQNQPYC LRIEPEMRRF
FENLNPMGSA SEKEFTDYLF NKSLEIEPRN CKQPPRFPRK STFSLKSPGI RPNTGRHGST
SGTLRGHPTP LEREPCKMSF SRIAETDIES TVSAPTSPNT PSTPPVSASS DLSVFLDVDL
SSSCGSNSIF APVLLPHSKS FFSSCGSLHK LSEEPLIPPP LPPRKKFEDD ASNSKGNTKS
DDDPPAIPPR QPPPPKVKPR APAPTGAFDG PLHSPPPPPP RDPLPDTPPP VPLRPPEHFL
NCPFNLQPPP LGHLHRDPDW FRDVSTCPNS PNTPPSTPSP RVPRRCYVLS SSHNHLAHPQ
APPVPPRQSS SPHLPNLPKL PPKTYKRELS HPPSFRLPVL ENAETPQ
//
