ID D2HMH9_AILME Unreviewed; 184 AA.
AC D2HMH9;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=Retina and anterior neural fold homeobox protein 2 {ECO:0000256|ARBA:ARBA00019389};
DE AltName: Full=Retina and anterior neural fold homeobox-like protein 1 {ECO:0000256|ARBA:ARBA00033377};
DE Flags: Fragment;
GN Name=RAX2 {ECO:0000313|Ensembl:ENSAMEP00000006231.1};
GN ORFNames=PANDA_012800 {ECO:0000313|EMBL:EFB13561.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB13561.1};
RN [1] {ECO:0000313|EMBL:EFB13561.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000006231.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in modulating the expression of photoreceptor
CC specific genes. Binds to the Ret-1 and Bat-1 element within the
CC rhodopsin promoter. {ECO:0000256|ARBA:ARBA00025251}.
CC -!- SUBUNIT: Interacts with CRX. {ECO:0000256|ARBA:ARBA00011785}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR EMBL; GL193044; EFB13561.1; -; Genomic_DNA.
DR RefSeq; XP_002923607.1; XM_002923561.3.
DR STRING; 9646.ENSAMEP00000006231; -.
DR Ensembl; ENSAMET00000006485.2; ENSAMEP00000006231.1; ENSAMEG00000005914.2.
DR GeneID; 100471207; -.
DR KEGG; aml:100471207; -.
DR CTD; 84839; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000163572; -.
DR HOGENOM; CLU_047013_4_0_1; -.
DR OMA; HIASLRM; -.
DR OrthoDB; 3042435at2759; -.
DR TreeFam; TF315976; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR043562; RAX/RAX2.
DR PANTHER; PTHR46271; HOMEOBOX PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR46271:SF2; RETINA AND ANTERIOR NEURAL FOLD HOMEOBOX PROTEIN 2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 25..85
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 27..86
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 184
FT /evidence="ECO:0000313|EMBL:EFB13561.1"
SQ SEQUENCE 184 AA; 20270 MW; 09245696948CB82D CRC64;
MFLSPGEGPA AEGGGPRPGE EAPKKQHRRN RTTFTTYQLH QLERAFEASH YPDVYSREEL
AAKVHLPEVR VQVWFQNRRA KWRRQERLES GSRAVAAPRL PEAPALPFAR PPAMPLPLEP
WLGPGPPAVP GLPRLLGPGP ALQAPFGPHA LGPAFTEGFC LEEASLRLLA KEHAQALDRA
WPPA
//
