ID D2HWC1_AILME Unreviewed; 1743 AA.
AC D2HWC1;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Meiosis regulator and mRNA stability factor 1 {ECO:0000256|ARBA:ARBA00022152};
DE AltName: Full=Limkain-b1 {ECO:0000256|ARBA:ARBA00030116};
DE Flags: Fragment;
GN ORFNames=PANDA_016760 {ECO:0000313|EMBL:EFB16230.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB16230.1};
RN [1] {ECO:0000313|EMBL:EFB16230.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
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DR EMBL; GL193540; EFB16230.1; -; Genomic_DNA.
DR RefSeq; XP_002927057.1; XM_002927011.3.
DR HOGENOM; CLU_002701_0_0_1; -.
DR InParanoid; D2HWC1; -.
DR OrthoDB; 5311892at2759; -.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR CDD; cd09977; LOTUS_1_Limkain_b1; 1.
DR CDD; cd09978; LOTUS_2_Limkain_b1; 1.
DR CDD; cd09979; LOTUS_3_Limkain_b1; 1.
DR CDD; cd09980; LOTUS_4_Limkain_b1; 1.
DR CDD; cd09981; LOTUS_5_Limkain_b1; 1.
DR CDD; cd09982; LOTUS_6_Limkain_b1; 1.
DR CDD; cd09983; LOTUS_7_Limkain_b1; 1.
DR CDD; cd09984; LOTUS_8_Limkain_b1; 1.
DR CDD; cd10910; PIN_limkain_b1_N_like; 1.
DR CDD; cd12255; RRM1_LKAP; 1.
DR CDD; cd12256; RRM2_LKAP; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 3.30.420.610; LOTUS domain-like; 6.
DR InterPro; IPR041966; LOTUS-like.
DR InterPro; IPR024768; Marf1.
DR InterPro; IPR045602; MARF1_LOTUS.
DR InterPro; IPR034189; MARF1_RRM1.
DR InterPro; IPR034191; MARF1_RRM2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021139; NYN.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR14379; LIMKAIN B LKAP; 1.
DR PANTHER; PTHR14379:SF82; MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1; 1.
DR Pfam; PF19687; MARF1_LOTUS; 1.
DR Pfam; PF11608; MARF1_RRM1; 1.
DR Pfam; PF01936; NYN; 1.
DR Pfam; PF12872; OST-HTH; 5.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS51644; HTH_OST; 7.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Oogenesis {ECO:0000256|ARBA:ARBA00022943};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 792..871
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 1004..1080
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1100..1174
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1176..1251
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1260..1335
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1336..1411
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1412..1486
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1487..1561
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT REGION 611..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1679..1729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1743
FT /evidence="ECO:0000313|EMBL:EFB16230.1"
SQ SEQUENCE 1743 AA; 192284 MW; D8E2710EFB036C7C CRC64;
MMEGSGTEDS CSRTPGWLQQ NNDAKPWLWK FSNCFSRPEQ TLPLSPQTKD YMENKKVAVE
LKDVPSPLHA GSKLFPAVPL PDIHSLQQPK IQLSPVPKVS CCAHCPNEPS TSPMHFGGGG
GGGSGGTGSL IHPGALLDSQ STRTITCQVG SGFAFQSASS LQNASARNNL AGIASDFPSM
CLESNLSACK HLPCCGKLHF QSCHGNVHKL HQFPALQGCA SAAYFPCSDF TSGAPGHLEE
HISQSELTPH LCTNSLHLNV VPPVCLKGSL YCEDCLNKPA RNSIIDAAKV WPNIPPPNTQ
TAPVTIPLCN GCGTKGTGKE TTLLLATSLG KASSKFGSPE VSLAGQVLEN LPPIGVFWDI
ENCSVPSGRS ATAVVQRIRE KFFKGHREAE FICVCDISKE NKEVIQELNN CQVTVAHINA
TAKNAADDKL RQSLRRFANT HTAPATVVLV STDVNFALEL SDLRHRHGFH IILVHKNQAS
EALLHHANEL IRFEEFISDL PPRLPLKMPQ CHTLLYVYNL PANKDGKSIS NRLRRLSDNC
GGKVLSITGC SAILRFINQD SAERAQKRME NEDVFGNRII VSFTPKTREL CETKSSSAIA
DKAKSPKKLK NPKLCLIKDT SEQSSSAKAT PGKGSQANSG SATKNTNVKS LQELCRMESK
TGTRNSDSQQ GNPRLAAPPH RSLSATAPVP KNSGTAESAY KTNPKKENLC ARSVTSSPVE
KKDKEETPFQ VSYPSAFSKL ITSRQVSPLL SAQSWSSRSM SPNLLNRASP LAFNIANPSI
GADSSDPFAN GADIQISNID YRLSRKELQQ LMQEAFSRHG KVKSVELSPH TDYQLKAVVQ
MENLQEAISA VNSLHRYKIG SKKILVSLAT GAANKSLSLL SAETMSILQD APACCLPLFK
FTDIYEKKFG HKLNVSDLYK LTDTVAIREQ GNGRLVCLLP SSQARQSPLG SSQSHDGSST
NCSPIIFEEL EYHEPVCRQH CSNKDFSEHE FDPDSYKIPF VILSLKTFAP QVHSLLQTHE
GTVPLLSFPD CYAAEFGDLE AVQENQGGVP LEHLITCVPG VNIATAQNGV KVVKWIHNKP
PPPNTDPWLL RSKSPVGNPQ LIQFSREVID LLKSQPSCVI PISNFIPSYH HHFAKQCRVS
DYGYSKLIEL LEAVPHVLQI LGMGSKRLLT LTHRAQVKRF TQDLLKLLKS QASKQVIVRE
FSQAYHWCFS KDWDVTEYGV CELIDIVSEI PDTTICLSQQ DNEMVICIPK RERTQDEIER
TKQFSKDVVD LLRHQPHFRM PFNKFIPSYH HHFGRQCKLA YYGFTKLLEL FEAIPDILQV
LECGEEKILT LTEVERFKAL AAQFVKLLRS QKDNCLMMTD LLTEYAKTFG YTFRLQDYDV
SSISALTQKL CHVVKIADME SGKQIQLINR KSLRALTAQL LVLLMSWEGT AHLSVDELKR
HYETTHSVPL NPCEYGFMTL TELLKSLPYL VEVFTNEKTE ECVKLTSLYL FAKNVRSLLH
TYHYQQLFLH EFSMAYTKYV GETLQPKTYG YSSVEELLGA IPQVVWIKGH GHKRIVVLKN
DMKSRLSSLG LAPTHPENQP SATEHIPAVP ESGIAVELEL GAGSDGPHQT DQELLRLTND
SPVDLLCAPV PSCLPSPQLR PDPVILQSAD LIQFEEHPPE PPEIMSLNQE EKIEIPVPVK
NHNPASDSGS SGISAAVPVP PCPSSETSES LPSKDPVESP AKKQPKNRVK LAANFSFAPI
TKL
//
