ID D2HY40_AILME Unreviewed; 2245 AA.
AC D2HY40;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
DE Flags: Fragment;
GN ORFNames=PANDA_017603 {ECO:0000313|EMBL:EFB21366.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB21366.1};
RN [1] {ECO:0000313|EMBL:EFB21366.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- FUNCTION: Collagen VI acts as a cell-binding protein.
CC {ECO:0000256|ARBA:ARBA00043858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the type VI collagen family.
CC {ECO:0000256|ARBA:ARBA00044000}.
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DR EMBL; GL193673; EFB21366.1; -; Genomic_DNA.
DR InParanoid; D2HY40; -.
DR CDD; cd01472; vWA_collagen; 4.
DR CDD; cd01450; vWFA_subfamily_ECM; 3.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 8.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF00092; VWA; 8.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 9.
DR SUPFAM; SSF53300; vWA-like; 9.
DR PROSITE; PS50234; VWFA; 9.
PE 3: Inferred from homology;
FT DOMAIN 6..178
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 208..386
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 415..585
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 601..770
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 788..961
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 979..1150
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1166..1358
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1738..1917
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1946..2151
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1380..1701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1455..1469
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB21366.1"
FT NON_TER 2245
FT /evidence="ECO:0000313|EMBL:EFB21366.1"
SQ SEQUENCE 2245 AA; 244886 MW; 848F2B079BE7D383 CRC64;
GPEYADVVFL VDSSDHLGTK SFPLVKAFIH RMVSSLPIEA HKYRVAVAQY SDRLHSEFQL
GTFKSRNPML NHLKKNLGFL GGSLRTGHAL REAHRTYFSA PAGGRDKKQF PPILVVLASA
QSEDDVEEAS KALREDGVRI VSVGLQSASE EELKAMATAQ FHFNLRSARD LGAFSQNMTQ
IIKEATQYKD GAADDILVEV CQGPSVADVV FLLDVSVNGS QENFEYLKEF LEESVSALDI
KEHCMRVGLV TYSNETKVIN SLSRGVNKSE VLQNIQNLSP WSGKAYTGAA IRKIRKEVFS
ARNGSRKNQG VPQIAVLVTH RPSEDNVTKA AVNLRREGVT IFTMGIEGAS DSQLEKIASH
PAEQHVSKLK TFSDLAAHNQ TFLKKLRNQI MHTVSVFSER TETLKSGCVD TEEADIYLLI
DGSGSTQATD FHEMKTFLSE VVGMFNIAPQ KVRVGAVQYA DSWDLEFEIN KYTNKHDLGK
AIENIRQMGG NTNTGAALNF TLGLLQKAKK QRGNRVPCHL VVLTNGMSKD SILEPANRLR
EELIRVYAIG VKEANQTQLR EIAGEEKRVY YVHDFDALKD IRNQVVQEIC AEEACKEMKA
DIMFLVDSSG SIGLENFIKM KTFMKNLVSK SQIGADRVQI GVVQFSDVNK EEFQLNRYMS
QNEISNAIDR MTHIGETTLT GSALTFVSQY FSPAKGARPN VRRFLILITD GEAQDIVKDP
AVALRQEGII IYSVGVFGSN VTQLEEISGR PEMVFYVENF DILQHIEDDL VFGICSPREE
CKRIEVLDVV FVIDSSGSID HDEYSIMKDF MVDLVKKADV GKNQVRFGAL KYADDPEVLF
YLGDLGSKWE VISVLQKDQP MGGNTYTAEA LGFSDHMFTE ARGSRLQKGV PQVLIVITDG
ESHDADKLNA TAKALRDKGI LVLAVGIAGA NPVELLAMAG SSDKYFFVET FGGLKGIFSD
VSASVCNSSK VDCEIEKVDL VFLMDGSNSI HPDDFRKMKE FLASVVQDFD VSVNRVRIGA
AQFSHTYRPE FPLGTFVGKK EISFQIENIQ QIFGYTHIGA ALRQVGHYFR PDMGSRINAG
TPQVLLVLTD GQSQDEVARA AEDLRHKGVD IYSVGIGDVD DQQLIQITGT AGKKLTVHNF
DELTKVKKRI VRNICTSGGE SNCFVDVVVG FDISTHENGQ TLLEGQSWIE TYLQDLLHTI
SSLNGVSCEV GTETQVSVAF QVTNAMEKYS PKFEIYSENI LNSLKDVTVK GPSLLNANLL
SSLWDAFQNK SAARGKVVLL FSDGLDDDIE KLEQKSDELR KEGLNALVTV ALDGATDSSD
LADLLYIEFG KGFEYRTQLT IGMRDLGSRL SKQLVNVAER TCCCLFCKCI GGDGIMGDPG
PPGKKGSPGF KGSEGYLGEE GIAGDRGAGG PVGEQGIKGC DGAKGPKGNR GLNGQEGEVG
ESGVGGLHGE QGESGLPGEK GEKGDEGSQG SPGKRGVSGD RGAKGQRGDP GVPGFDNTIE
GPKGLKGERG RQGRRGWPGP PGTPGSRRKT AAHGRRGHTG PQGKTGIPGP DGLEGSWGLK
GPQGPRGETG VKGEKGGLGS EGPQGPPGPG GEAGSPGHLG SQGNKGEPGD LGEKGAIGLP
GPRGLPGDDG NPGYGSLGSK GAKGQEGFPG ESGPKGETGD PGGPGETGPK GARGMTISNG
PPGEMGSPGE PGPPGRKGVK GARGLASFSM CELIQYVRDH SPCSCLPGEP ECPVHPTELV
FALDQSRDVT KQEFERMKEL MSSLVRGVRV RETSCPVGAR IAILTYTSHA RHLVRFSDAY
RKQQLLREIE AIPYERSSDS REIGKVMRFI SRNVFKRTLP GAHTRRIATF FSSGQSADAQ
TIATATMEFS ALDIIPVVIA FSNVPSVKRA FAIDDTGTFQ VIMVPSGTDY APALERLQRC
TFCYDVCKPD AFCDQAKPPP AQSYMDAAFL LDSSRHVGSA EFEDIRHFLG ALLDHFEITP
EPGTSVTGDR VALLSHAPPN FLPNTQKSPV RTEFNLTTYN SKRLMRRHLE KSVQQLNGDA
FIGHALQWTL DNIFLNTPNM RRNKVIFVIS AGETSHLDKE TLKKESLRAK CQGYALFVFS
LGPAWNDKEL EDLASYPLDH HLVQLGRIHK PDHRYSVKIV RAFINSIRRA INKYPPINFK
MKCSRLSSTD LKQPARQWRS FVPGPHKTAL KEDALQKAKF FQDKKYLSRV ARGSRDDTIR
NLTRNTFHAF KNGKKVIKTA PNQHD
//
