ID D2I180_AILME Unreviewed; 594 AA.
AC D2I180;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=RNA-binding protein 47 {ECO:0000256|ARBA:ARBA00015191};
DE AltName: Full=RNA-binding motif protein 47 {ECO:0000256|ARBA:ARBA00030579};
DE Flags: Fragment;
GN ORFNames=PANDA_019026 {ECO:0000313|EMBL:EFB18199.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB18199.1};
RN [1] {ECO:0000313|EMBL:EFB18199.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM RBM47 family.
CC {ECO:0000256|ARBA:ARBA00005319}.
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DR EMBL; GL193960; EFB18199.1; -; Genomic_DNA.
DR RefSeq; XP_011235152.1; XM_011236850.2.
DR AlphaFoldDB; D2I180; -.
DR STRING; 9646.ENSAMEP00000010159; -.
DR eggNOG; KOG0117; Eukaryota.
DR HOGENOM; CLU_022960_4_2_1; -.
DR InParanoid; D2I180; -.
DR OMA; RTGYTMI; -.
DR OrthoDB; 3184171at2759; -.
DR TreeFam; TF314932; -.
DR GO; GO:0030895; C:apolipoprotein B mRNA editing enzyme complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0140767; F:enzyme-substrate adaptor activity; IEA:Ensembl.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:Ensembl.
DR GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IEA:Ensembl.
DR GO; GO:0016554; P:cytidine to uridine editing; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR CDD; cd12491; RRM2_RBM47; 1.
DR CDD; cd12497; RRM3_RBM47; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR006535; HnRNP_R/Q_splicing_fac.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034440; RBM47_RRM2.
DR InterPro; IPR034445; RBM47_RRM3.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01648; hnRNP-R-Q; 1.
DR PANTHER; PTHR21245; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; 1.
DR PANTHER; PTHR21245:SF6; RNA-BINDING PROTEIN 47; 1.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 3.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 71..144
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 151..233
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 246..318
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT NON_TER 594
FT /evidence="ECO:0000313|EMBL:EFB18199.1"
SQ SEQUENCE 594 AA; 64178 MW; 5E244823B97785DF CRC64;
MTAEDSTAAM SSDSAAAALA KVPEGVAGAP NEAALLALME RTGYSMVQEN GQRKYGGPPP
GWEGPHPQRG CEVFVGKIPR DVYEDELVPV FEAVGRIYEL RLMMDFDGKN RGYAFVMYCH
KSEAKRAVRE LNNYEIRPGR LLGVCCSVDN CRLFIGGIPK MKKREEILEE IAKVTEGVLD
VIVYASAADK MKNRGFAFVE YESHRAAAMA RRKLMPGRIQ LWGHQIAVDW AEPEIDVDED
VMETVKILYV RNLMIETTED TIKKSFGQFN PGCVERVKKI RDYAFVHFVS REDAVHAMNN
LNGTELEGSC LEVTLAKPVD KEQYSRYQKA AKGGGAAEAA VQQPSYVYSC DPYTLAYYGY
PYNALIGPNR DYFVKAGSIR GRGRGAAGNR APGPRGSYLG GYSAGRGIYS RYHEGKGKQQ
EKGYELVPNL EISAVNPVAI KPGTVAIPAI GAQYSMFQAA PAPKMIEDGK IHTMEHMISP
IAVQPDPASA AAAAAAAAAA AAAATVIPAV STPPPFQGRP MTPVYTVAPN IQRIPTAGIY
GASYVPFAAP ATATLATLQK SAAAAVYGGY AGYIPQAFPA AAIQVPIHDV YQTY
//
