ID D2I1W1_AILME Unreviewed; 773 AA.
AC D2I1W1;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Cullin-5 {ECO:0000256|ARBA:ARBA00040451};
DE Flags: Fragment;
GN ORFNames=PANDA_019319 {ECO:0000313|EMBL:EFB27801.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB27801.1};
RN [1] {ECO:0000313|EMBL:EFB27801.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; GL194057; EFB27801.1; -; Genomic_DNA.
DR AlphaFoldDB; D2I1W1; -.
DR InParanoid; D2I1W1; -.
DR UniPathway; UPA00143; -.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF76; CULLIN-5; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 396..631
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB27801.1"
FT NON_TER 773
FT /evidence="ECO:0000313|EMBL:EFB27801.1"
SQ SEQUENCE 773 AA; 90211 MW; CD51D9ED738AAF81 CRC64;
KNKGSLQFED KWDFMRPIVL KLLRQESVTK QQWFDLFSDV HAVCLWDDKG PAKIHQALKE
DILEFIKQAQ ARVLSHQDDT ALLKAYIVEW RKFFTQCDIL PKPFCQLEIT LMGKQGSNKK
STVEDSIVRK LMLDTWNESI FSNIKNRLQD SAMKLVHAER LGEAFDSQLV IGVRESYVNL
CSNPEDKLQI YRDNFEKAYL DSTERFYRTQ APSYLQQNGV QNYMKYADAK LKEEEKRALR
YLETRRECNS VEALMECCVN ALVTSFKETI LAECQGMIKR NETEKLHLMF SLMDKVPNGI
EPMLKDLEEH IISAGLADMV AAAETITTDS EKYVEQLLTL FNRFSKLVKE AFQDDPRFLT
ARDKAYKAVV NDATIFKLEL PLKQKGVGLK TQPESKCPEL LANYCDMLLR KTPLSKKLTS
EEIEAKLKEV LLVLKYVQNK DVFMRYHKAH LTRRLILDIS ADSEIEENMV EWLREVGMPA
DYVNKLARMF QDIKVSEDLN QAFKEMHKNN KLALPADSVN IKILNAGAWS RSSEKVFVSL
PTELEDLIPE VEEFYKKNHS GRKLHWHHLM SNGIITFKNE VGQYDLEVTT FQLAVLFAWN
QRPREKISFE NLKLATELPD AELRRTLWSL VAFPKLKRQV LLYEPQVNSP KDFTEGTLFS
VNQEFSLIKN AKVQKRGKIN LIGRLQLTTE RMREEENEGI VQLRILRTQE AIIQIMKMRK
KISNAQLQTE LVEILKNMFL PQKKMIKEQI EWLIEHKYIR RDESDINTFI YMA
//
