ID D2I1Y7_AILME Unreviewed; 686 AA.
AC D2I1Y7;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 13-SEP-2023, entry version 63.
DE RecName: Full=MTSS I-BAR domain containing 1 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=PANDA_019348 {ECO:0000313|EMBL:EFB23896.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB23896.1};
RN [1] {ECO:0000313|EMBL:EFB23896.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
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DR EMBL; GL194070; EFB23896.1; -; Genomic_DNA.
DR AlphaFoldDB; D2I1Y7; -.
DR HOGENOM; CLU_004805_2_0_1; -.
DR InParanoid; D2I1Y7; -.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0071498; P:cellular response to fluid shear stress; ISS:UniProtKB.
DR GO; GO:2001013; P:epithelial cell proliferation involved in renal tubule morphogenesis; ISS:UniProtKB.
DR GO; GO:0072102; P:glomerulus morphogenesis; ISS:UniProtKB.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISS:UniProtKB.
DR GO; GO:0072160; P:nephron tubule epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR GO; GO:0061333; P:renal tubule morphogenesis; ISS:UniProtKB.
DR CDD; cd22060; WH2_MTSS1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR013606; I-BAR_dom.
DR InterPro; IPR030127; MTSS1/MTSS2.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR15708; ACTIN BUNDLING/MISSING IN METASTASIS-RELATED; 1.
DR PANTHER; PTHR15708:SF10; PROTEIN MTSS 1; 1.
DR Pfam; PF08397; IMD; 1.
DR Pfam; PF02205; WH2; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51338; IMD; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
FT DOMAIN 1..181
FT /note="IMD"
FT /evidence="ECO:0000259|PROSITE:PS51338"
FT DOMAIN 658..675
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 70..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..632
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB23896.1"
FT NON_TER 686
FT /evidence="ECO:0000313|EMBL:EFB23896.1"
SQ SEQUENCE 686 AA; 74479 MW; 1D307E625ABFA9FB CRC64;
GGTREIGSAL TRMCMRHRSI EAKLRQFSSA LIDCLINPLQ EQMEEWKKVA NQLDKDHAKE
YKKARQEIKK KSSDTLKLQK KAKKGRGDIQ PQLDSALQDV NDKYLLLEET EKQAVRKALI
EERGRFCTFI SMLRPVIEEE ISMLGEITHL QTISEDLKSL TMDPHKLPSS SEQVILDLKG
SDYSWSYQTP PSSPSTTMSR KSSVCSSLNS VNSSDSRSSG SHSHSPSSHY RYRSSNLAQQ
APVRLSSVSS HDSGFISQDA FQSKSPSPMP PEAPNQLSNG FSHCSLPSES HVGPVGASLS
PHCLPASRLL PRVTSVHLPD FAHYHTIGPG MFPSSQIPSW KDWAKPGPYD QPLVNTLQRR
KEKREPDPNG GGPTAAGGAP AAAEEAQRPR SMTVSAATRP GEEMEACEEL ALALSRGLQL
DTQRSSRDSL QCSSGYSTQT TTPCCSEDTI PSQVSDYDYF SVSGDQEADQ QEFDKSSTIP
RNSDISQSYR RMFQAKRPAS TAGLPTTLGP AMVTPGVATI RRTPSTKPSV RRGTIGAGPI
PIKTPVIPVK TPTVPDLLGV LPAPPDGPEE RGEHSPESPS VGEGPQGVTS MPSSMWSGQA
SVNPPLPGPK PSIPEEHRQA IPESEAEDQE RDPASATASP GQIPESDPAD LSPRDTPQGE
DMLNAIRRGV KLKKTTTNDR SAPRFS
//
