ID D2I2T2_AILME Unreviewed; 641 AA.
AC D2I2T2;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
DE Flags: Fragment;
GN ORFNames=PANDA_019732 {ECO:0000313|EMBL:EFB20448.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB20448.1};
RN [1] {ECO:0000313|EMBL:EFB20448.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
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DR EMBL; GL194206; EFB20448.1; -; Genomic_DNA.
DR AlphaFoldDB; D2I2T2; -.
DR HOGENOM; CLU_014510_0_0_1; -.
DR InParanoid; D2I2T2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR CDD; cd01210; PTB_EPS8; 1.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF20; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 436..495
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 128..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..422
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB20448.1"
FT NON_TER 641
FT /evidence="ECO:0000313|EMBL:EFB20448.1"
SQ SEQUENCE 641 AA; 72565 MW; D2AB2D498AEB6740 CRC64;
QHLATFIMDK SEAIATVDDA IRKLVQLSSK EKVWAQEMLL QVNDQSLRLL DVESQEELEN
FPLPTVRHSQ TVLNQLRYPS VLLLVCQDSE QSKPDIHFFH CDEVEAELVH EDIESALADC
RLGKKMRPQT LKGHQEKIRQ EPPKGPAPIP FQRYGSDAPS TKNRVGPPMP LPEPSFRRRE
SLDEEPRAVL AQKIEKETQI LNCALDDIEW FVARLQKAAE AFKQLNQRKK WKKKGKKGPA
EGVLTLRARP PSEAQFIDCF QKIKLAVNLL AKLQKHIQNP SAAELVHFLF GPLELIVSTC
GGPDIARSVS SPLLSREAVG FLRGHLVPKE MTLWESLGEM WTRPRSEWPQ EPQVPLYVPK
FHSGWEPPLD VLQEAPWEVE GLASAPDDEP TLVNRPSFRN SPKHSLVSEP TAPPPGDPLP
PVSSPHAHRG YEPGPAMTKY VRILYDFTAR NANELSVLKD EVLEVLEDGH QWWKVRNRSG
QAGYVPCNIL DETRLEDAPQ EQASLKYWGP ASPTHKLPPS FAGNKDELIH HMDEVNDELI
KKISHIKAQP QRHFRVERSQ PLSLPPPRPA PRIVENLGIL TGPQLFSLNK DELKKVCGEE
GIRVYSQLTV QKAVLEKQQG GSELEELISK FHSKTQRRVE E
//
