ID D2I4N7_AILME Unreviewed; 2005 AA.
AC D2I4N7;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Dynein axonemal heavy chain 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PANDA_020575 {ECO:0000313|EMBL:EFB22609.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB22609.1};
RN [1] {ECO:0000313|EMBL:EFB22609.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; GL194519; EFB22609.1; -; Genomic_DNA.
DR InParanoid; D2I4N7; -.
DR GO; GO:0005929; C:cilium; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF14; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF18199; Dynein_C; 2.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 151..230
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 307..567
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 583..812
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 839..968
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 998..1218
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 1473..1581
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 1613..1752
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 1761..1878
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT DOMAIN 1879..2002
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 591..625
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 860..908
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2005 AA; 229540 MW; 1E2352D1BB16187D CRC64;
MCKRDIMEFL RTIESYVDKR MGTTYGPPAG KKMTVFIDDV NMPIINEWGD QVTNEIVRQL
MEQNGFYNLE KPGEFTSIVD IQFLAAMIHP GGGRSDIPQR LKRQFCIFNC TLPSDASMDK
IFGVIGRGYY CAQRGFSEEV RDSVMRLVPL TRRLWQMTKN KMLPTPAKFH YVFNLRDLSR
IWQGMLNTTS EVIKEPDELL RLWKHECKRV IADRFTVSSD VTWFDKALVG LVEEGFGEEK
KLLVDCGTDA YFVDFLRDAP EATGETSEEA DAEMPKIYEP IESFDHLKER LNMFLQLYNE
SIRGAGMDLV FFKDAMVHLV RISRVIGTPR GNALLVGVGG SGKQSLTRLA SFIAGYASFQ
IALTRSYNTS NLVEDLKILY RTAGQQGKGI TFIFTDNEIK DESFLEYMNN VLSSGEVSNL
FARDEIDEIN CDLLSVMKKE YPRRPPTNEN LHDYFMSRVR QNLHIVLCFS PVGEKFRNRA
LKFPALISGC TIDWFSRWPK DALVAVSEHF LSSYDIDCSL ETKRQVVQCM GSFQDGVAEK
CVDYFQRFRR STHVTPKSYL SFIQGYKCTY REKHVEVQTL ANRMNTGLEK LKEASESIAA
LSKELQVKEK ELQVANDKAD TVLKEVTMKA QAAEKVKAEV QKVKDKAQAI VDGISKDKAV
AEEKLERAKP ALGEAEAALQ TIKPSDIATV RTLGRPPHLI MRIMDCVLLL FQRKVNAVKI
DLEKSCTIPS WQESLKLMTA GNFLQNLQQF PKDTINEEVI EFLNPYFEMT DYNIETAKRV
CGNVAGLCSW TKAMASFFSI NREVLPLKQL AETLGVERRT GMSFAEISDE MLAVWLAAHY
PSFTLVRPVQ ANLVVQENRY ILAMQDLQKA QAELDDKQRE LDVVQAEYEQ AMTEKQTLLE
DAERCRRKMQ TASTLIGGLA GEKERWTEQS KEFAAQTKRL VGDVLLATAF LSYSGPFNQE
FRNLLLNDWQ KEMKVREIPF GDNLNLNEML IDAPTVSEWN LQGLPNDDLS IQNGIIVTKA
SRYPLLIDPQ TQGKMWIKNK ESQNELQITS LNHKYFRNHL EDSLSLGRPL LIEDVGEELD
PALDNVLERN FIKTGSTFKV KVGDKEVDVM DGFRLYITTK LPNPAYTPEI SARTSLIDFT
VTMKGLEDQL LGRVILTEKR ELEKERTHLM EDVTANKRRM KELEDNLLYR LTSTQGSLVE
DESLIVVLSN TKKTAEEVTQ KLEISAETEI QINSAREEYR PAHATLLCLS VATRGSILYF
LLTEMRLVNE MYQTSLRQFL GLFDLSLARS VKSPITSKRI ANIIEHMTYE VYKYAARGLY
EEHKFLFTLL LTLKIDIQRN RVKHEEFLTL IKGGASLDLK ACPPKPSKWI LDMTWLNLVE
LSKLRQFSDV LDQISRNEKM WKIWFDKENP EEEPLPNAYD KSLDCFRRLL LIRSWCPDRT
IAQARKYIMD SMGERYAEGV ILDLEKTWEE SDPRTPLICL LSMGSDPTDS IIALGKRLKI
ETRYVSMGQG QEVHARKLLQ QTMANGGWAL LQNCHLGLDF MDELMDIIIE TDTVHDAFRL
WMTTEVHKHF PITLLQMAIK FANEPPQGLR AGLKRTYGGV SQDLLDVSTA AQWKPMLYAV
AFLHSTVQER RKFGPLGWNI PYEFNQADFN ATVQFIQNHL DDMDVKKGVS WTTIRYMVGE
IQYGGRVTDD YDKRLLNAFA KVWFSEDMFG SDFSFYQGYD IPQCNAVDNY LQYIQSLPTY
DSPEVFGLHP NADITYQSKL AKDVLDTILS IQPKDSSGGA DETREAVVAR LADDMLEKLP
PDYSPFEVKE RLQKMGPFQP MNIFLRQEID RMQRLLTLVR STLTELKLAI DGTIIMSEDL
GDALNSMFDA RIPARWKKEI TRANKGWALD NMVLCNEVTK WMKDDISAPP TEGVYVYGLY
LEGAGWDKRN MKLIESKPKV LFELMPVIRI YAENNTLRDP QFYSCPIYKK PVRTDLNYIA
AVDLRTAQVP EHWVLRGVAL LCDVK
//
