ID D2JBD1_ENTFC Unreviewed; 575 AA.
AC D2JBD1;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=ABC transporter permease subunit {ECO:0000313|EMBL:KAB7578009.1};
DE SubName: Full=ABC transporter permease/substrate binding protein {ECO:0000313|EMBL:MBX4221677.1};
DE SubName: Full=Glycine betaine ABC transport system, permease protein OpuAB / Glycine betaine ABC transport system, glycine betaine-binding protein OpuAC {ECO:0000313|EMBL:ADA62230.1};
DE SubName: Full=Glycine/betaine ABC transporter permease {ECO:0000313|EMBL:AQY31713.1};
GN Name=proWX {ECO:0000313|EMBL:BDP58348.1};
GN ORFNames=B4W81_06825 {ECO:0000313|EMBL:AQY31713.1}, EfmJHP36_28270
GN {ECO:0000313|EMBL:BDP58348.1}, FHK66_12270
GN {ECO:0000313|EMBL:QDA39191.1}, GBM73_12225
GN {ECO:0000313|EMBL:KAB7578009.1}, KYX88_02265
GN {ECO:0000313|EMBL:MBX4221677.1}, SAP083A_009
GN {ECO:0000313|EMBL:ADA62230.1};
OS Enterococcus faecium (Streptococcus faecium).
OG Plasmid p5753cA {ECO:0000313|EMBL:ADA62230.1}.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1352 {ECO:0000313|EMBL:ADA62230.1};
RN [1] {ECO:0000313|EMBL:ADA62230.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=5753c {ECO:0000313|EMBL:ADA62230.1};
RC PLASMID=p5753cA {ECO:0000313|EMBL:ADA62230.1};
RA Gill J., Borman J., Shetty J., Hostetler J., Durkin S., Montgomery B.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADA62230.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=5753c {ECO:0000313|EMBL:ADA62230.1};
RC PLASMID=p5753cA {ECO:0000313|EMBL:ADA62230.1};
RA Summers A.O., Shearer J., Wireman J.;
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AQY31713.1, ECO:0000313|Proteomes:UP000190755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2014-VREF-268 {ECO:0000313|EMBL:AQY31713.1};
RA Kim H.M.;
RT "Non-typeable vancomycin-resistant E. faecium.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:QDA39191.1, ECO:0000313|Proteomes:UP000308289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F17E0263 {ECO:0000313|EMBL:QDA39191.1,
RC ECO:0000313|Proteomes:UP000308289};
RA Li C., Zhao S.;
RT "Enterococcus faecium from chicken.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:KAB7578009.1, ECO:0000313|Proteomes:UP000469871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VRECG27 {ECO:0000313|EMBL:KAB7578009.1,
RC ECO:0000313|Proteomes:UP000469871};
RA Chilambi G.S., Nordstrom H.R., Evans D.R., Ferrolino J., Hayden R.T.,
RA Maron G.M., Vo A.N., Gilmore M.S., Wolf J., Rosch J.W., Van Tyne D.;
RT "Evolutionary dynamics of vancomycin-resistant Enterococcus faecium during
RT gastrointestinal tract colonization and bloodstream infection in
RT immunocompromised pediatric patients.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:MBX4221677.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EF215 {ECO:0000313|EMBL:MBX4221677.1};
RX PubMed=35150575; DOI=10.1093/jas/skac030;
RA Shridhar P.B., Amachawadi R.G., Tokach M., Patel I., Gangiredla J.,
RA Mammel M., Nagaraja T.G.;
RT "Whole genome sequence analyses-based assessment of virulence potential and
RT antimicrobial susceptibilities and resistance of Enterococcus faecium
RT strains isolated from commercial swine and cattle probiotic products.";
RL J. Anim. Sci. 100:skac030-skac030(2022).
RN [7] {ECO:0000313|EMBL:BDP58348.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JHP36 {ECO:0000313|EMBL:BDP58348.1};
RA Hashimoto Y., Suzuki M., Tomita H.;
RT "Analysis of enterococcal linear plasmids.";
RL Submitted (AUG-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363032};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363032}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000256|RuleBase:RU363032}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the OsmX family.
CC {ECO:0000256|ARBA:ARBA00035642}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the binding-protein-
CC dependent transport system permease family.
CC {ECO:0000256|ARBA:ARBA00035652}.
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DR EMBL; GQ900435; ADA62230.1; -; Genomic_DNA.
DR EMBL; CP019992; AQY31713.1; -; Genomic_DNA.
DR EMBL; AP026586; BDP58348.1; -; Genomic_DNA.
DR EMBL; WEFP01000001; KAB7578009.1; -; Genomic_DNA.
DR EMBL; JAIFOC010000017; MBX4221677.1; -; Genomic_DNA.
DR EMBL; CP040849; QDA39191.1; -; Genomic_DNA.
DR RefSeq; WP_002287807.1; NZ_WVTH01000009.1.
DR RefSeq; YP_006937535.1; NC_013317.1.
DR STRING; 1352.AL014_14605; -.
DR GeneID; 66455291; -.
DR PATRIC; fig|1352.1358.peg.2364; -.
DR OMA; SPHWAYS; -.
DR Proteomes; UP000190755; Chromosome.
DR Proteomes; UP000308289; Chromosome.
DR Proteomes; UP000469871; Unassembled WGS sequence.
DR Proteomes; UP001061325; Chromosome.
DR Proteomes; UP001139644; Unassembled WGS sequence.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd13639; PBP2_OpuAC_like; 1.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; MetI-like; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR007210; ABC_Gly_betaine_transp_sub-bd.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR PANTHER; PTHR47737; GLYCINE BETAINE/PROLINE BETAINE TRANSPORT SYSTEM PERMEASE PROTEIN PROW; 1.
DR PANTHER; PTHR47737:SF1; GLYCINE BETAINE_PROLINE BETAINE TRANSPORT SYSTEM PERMEASE PROTEIN PROW; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR Pfam; PF04069; OpuAC; 1.
DR SUPFAM; SSF161098; MetI-like; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363032};
KW Plasmid {ECO:0000313|EMBL:ADA62230.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363032};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363032};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363032}.
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 74..91
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 97..120
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 141..168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 221..240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 252..269
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 298..319
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT DOMAIN 94..273
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50928"
SQ SEQUENCE 575 AA; 62897 MW; E4F4F67099AB4234 CRC64;
MNNLLNYQLP VANWVENITE WFTTTFSGLF SFLQTIGQAV MSGITNLLLV IPAPLFILLL
TVAAFFISKK RPGLTLFTLI GLWFIYNQGL WNDLMNTVTL VLLSSVISII IGVPLGILMA
KSSKAQSIIK PILDFMQTMP GFVYLIPAVA FFGIGMVPGV FASVIFALPP TVRFTNLGIR
QVPKELVEAS DSFGSTSRQK LFKLELPLAK STIMAGINQT TMLSLSMVVI ASMIGAPGLG
RGVLSALQRA QVGNGFVNGV ALVILAIIID RFTQHLNQPN NKKAAGATTQ KSKKRQGLII
GAVVVVILGA IGIGSFSSAK ETKRINLSYV EWDTEVASTN VVGEVLKQMG YDVTMTPLDN
SIMWKSVSNG ESDAMVSAWL PKTHGSQYAQ YKDQVEDLGA NLTGAKVGLA VPAYMDVNSI
DELTDQAGKK IIGIEPGAGV VTAAENTIQK YDNLKDWKVE TSSSGAMTVA LGQAIKKHEP
IVVTGWTPHW MFAKYDLKYL EDPENGMGSE EQIHTMVRKG LKEDQPEAYK VLDNFHWSEK
DMEKVMLEIN NGKDPQQAAK DWIKENQELV ESWKK
//
