ID D2JET5_ENTFC Unreviewed; 641 AA.
AC D2JET5;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Tetracycline resistance protein TetM {ECO:0000313|EMBL:ADA62733.1};
GN Name=tetM {ECO:0000313|EMBL:ADA62733.1};
GN ORFNames=SAP083B_035 {ECO:0000313|EMBL:ADA62733.1};
OS Enterococcus faecium (Streptococcus faecium).
OG Plasmid p5753cB {ECO:0000313|EMBL:ADA62733.1}.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1352 {ECO:0000313|EMBL:ADA62733.1};
RN [1] {ECO:0000313|EMBL:ADA62733.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=5753c {ECO:0000313|EMBL:ADA62733.1};
RC PLASMID=p5753cB {ECO:0000313|EMBL:ADA62733.1};
RA Gill J., Borman J., Shetty J., Hostetler J., Durkin S., Montgomery B.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADA62733.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=5753c {ECO:0000313|EMBL:ADA62733.1};
RC PLASMID=p5753cB {ECO:0000313|EMBL:ADA62733.1};
RA Summers A.O., Shearer J., Wireman J.;
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
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DR EMBL; GQ900487; ADA62733.1; -; Genomic_DNA.
DR RefSeq; WP_000691722.1; NZ_WLYR01000001.1.
DR AlphaFoldDB; D2JET5; -.
DR SMR; D2JET5; -.
DR GeneID; 66817191; -.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR CDD; cd03711; Tet_C; 1.
DR CDD; cd03690; Tet_II; 1.
DR CDD; cd16258; Tet_III; 1.
DR CDD; cd01684; Tet_like_IV; 1.
DR CDD; cd04168; TetM_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR PRINTS; PR01037; TCRTETOQM.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plasmid {ECO:0000313|EMBL:ADA62733.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 1..242
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 641 AA; 73014 MW; EC534FD38FD54FC2 CRC64;
MKIINIGILA HVDAGKTTLT ESLLYSSGAI KELGSVDSGT TKTDTMFLER QRGITIQTAI
TSFQRENVKV NIVDTPGHMD FLADVYRSLS VLDGAILLIS AKDGVQSQTR ILFHALRKMN
IPIIFFINKI DQNGINLPDV YQDIKDKLSD DIIIKQTVNL NLKPYVIDYT EPEQWETVIV
GNDYLLEKYT IGKTLNIAEL EKEENERIQS CSLYPVYHGS AKNNIGIKQL IEVITSKLFS
PTQLNSDKLC GNVFKVEYSD DGQRLVYVRL YSGTLHLRDS VNISEKEKIK VTEMYTSING
ELRQIDKAEP GEIIILKNEL LKLNNVLGDK KRLPHREILE NPLPMLQTTI EPCKSVQREK
LLDALFEISD SDPLLQYYVD TVTHEIVLSF LGEVQMEVTC TLIQEKYHIE IETRKPTVIY
MERPLKKSEF TIDIEVPPNP FWASIGLSVT PLPLGSGIQY ESLVSLGYLN QSFQNAVMEG
IRYGCEQGLY GWKLTDCKIC FKYGLYYSPV STPADFRMLA PIVLEQAFRK SGTELLEPYL
SFEIYVPQEY LSRAYNDASK YCANILNTKL KGNEVILIGE IPARCIQEYR NSLTFFTNGR
SVCLTELKGY QVTNIKSAFQ PRRPNNRIDK VRHMFNKINL H
//
