ID D2K246_CYAGR Unreviewed; 454 AA.
AC D2K246;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Elongation factor 1-alpha {ECO:0000256|RuleBase:RU000325};
DE Flags: Fragment;
GN Name=EF-1a {ECO:0000313|EMBL:ACZ58329.1};
OS Cyamus gracilis (Whale louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Peracarida; Amphipoda; Senticaudata;
OC Corophiida; Caprellidira; Caprelloidea; Cyamidae; Cyamus.
OX NCBI_TaxID=335538 {ECO:0000313|EMBL:ACZ58329.1};
RN [1] {ECO:0000313|EMBL:ACZ58329.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GsSA5b10 {ECO:0000313|EMBL:ACZ58329.1}, and GsSA5b14
RC {ECO:0000313|EMBL:ACZ58330.1};
RX PubMed=19966069; DOI=10.1534/genetics.109.103556;
RA Seger J., Smith W.A., Perry J.J., Hunn J., Kaliszewska Z.A., Sala L.L.,
RA Pozzi L., Rowntree V.J., Adler F.R.;
RT "Gene genealogies strongly distorted by weakly interfering mutations in
RT constant environments.";
RL Genetics 184:529-545(2010).
CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC tRNA to the A-site of ribosomes during protein biosynthesis.
CC {ECO:0000256|ARBA:ARBA00003982, ECO:0000256|RuleBase:RU000325}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249,
CC ECO:0000256|RuleBase:RU000325}.
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DR EMBL; GU172349; ACZ58329.1; -; Genomic_DNA.
DR EMBL; GU172350; ACZ58330.1; -; Genomic_DNA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd03693; EF1_alpha_II; 1.
DR CDD; cd03705; EF1_alpha_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004539; Transl_elong_EF1A_euk/arc.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR NCBIfam; TIGR00483; EF-1_alpha; 1.
DR PANTHER; PTHR23115:SF170; ELONGATION FACTOR 1-ALPHA 2; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000256|RuleBase:RU000325,
KW ECO:0000313|EMBL:ACZ58329.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000325};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000325};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein biosynthesis {ECO:0000256|RuleBase:RU000325,
KW ECO:0000313|EMBL:ACZ58329.1}.
FT DOMAIN 1..235
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACZ58329.1"
SQ SEQUENCE 454 AA; 50133 MW; 41B3FE9F43AF1484 CRC64;
ISIVVVGHVD SGKSTTTGHL IYKCGGIDKR TIEKFEKESA EMGKGSFKYA WVLDKLKAER
ERGITIDIAL WKFETSRYFV TIIDAPGHRD FIKNMITGTS QADCAVLIVA AGTGEFEAGI
SKNGQTREHV LLCFTLGVKQ IIIAVNKMDS TEPKYSEDRF KEIHKEVYAY VKKVGYNPAT
VPVVPISGFN GDNMLEKSDK MXWWKKQKIE RKNGSYEFET LLDCLDNIDP PARPTDKALR
LPLQDVYKIG GIGTVPVGRV ETGIIKPGMV VNFAPNGPTT EVKSVEMHHE SLTQANPGDN
VGFNVKNVSV KDLKRGFVTS DSKNDPAKEA QDFLAQVIVL NHPGQIQAGY SPVLDCHTAH
IACRFGELKT KIDRRTGKEL EASPKFVKSG DSCIVKMIPS KPMCVESFQQ YSALGRFAVR
DMKQTVAVGV IKEVTKKDAS SKTTKSADKA LKKK
//
