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Database: UniProt
Entry: D2KAF9_9TELE
LinkDB: D2KAF9_9TELE
Original site: D2KAF9_9TELE 
ID   D2KAF9_9TELE            Unreviewed;       301 AA.
AC   D2KAF9;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
DE   Flags: Fragment;
GN   Name=GRIA2B {ECO:0000313|EMBL:ACZ73268.1};
OS   Brachyhypopomus gauderio.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gymnotiformes;
OC   Sternopygoidei; Hypopomidae; Brachyhypopomus.
OX   NCBI_TaxID=698409 {ECO:0000313|EMBL:ACZ73268.1};
RN   [1] {ECO:0000313|EMBL:ACZ73268.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Quintana L., Harvey-Girard E., Maler L., Macadar O.;
RT   "Pacemaker nucleus function and structure of Brachyhypopomus gauderio.";
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC       channel in the central nervous system and plays an important role in
CC       excitatory synaptic transmission. L-glutamate acts as an excitatory
CC       neurotransmitter at many synapses in the central nervous system.
CC       {ECO:0000256|RuleBase:RU367118}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC       Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Endoplasmic
CC       reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic density membrane
CC       {ECO:0000256|ARBA:ARBA00037872}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00037872}.
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. GRIA2 subfamily. {ECO:0000256|ARBA:ARBA00037989}.
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DR   EMBL; GU192370; ACZ73268.1; -; mRNA.
DR   AlphaFoldDB; D2KAF9; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR001508; Iono_Glu_rcpt_met.
DR   InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR   InterPro; IPR001320; Iontro_rcpt_C.
DR   InterPro; IPR001638; Solute-binding_3/MltF_N.
DR   PANTHER; PTHR18966:SF99; GLUTAMATE RECEPTOR 2; 1.
DR   PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR   Pfam; PF00060; Lig_chan; 1.
DR   Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR   Pfam; PF00497; SBP_bac_3; 1.
DR   PRINTS; PR00177; NMDARECEPTOR.
DR   SMART; SM00079; PBPe; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU367118};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Ion channel {ECO:0000256|RuleBase:RU367118};
KW   Ion transport {ECO:0000256|RuleBase:RU367118};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW   ECO:0000256|RuleBase:RU367118};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW   ECO:0000256|RuleBase:RU367118};
KW   Receptor {ECO:0000256|RuleBase:RU367118, ECO:0000313|EMBL:ACZ73268.1};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU367118};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU367118};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   TRANSMEM        54..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367118"
FT   TRANSMEM        136..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367118"
FT   DOMAIN          1..301
FT                   /note="Ionotropic glutamate receptor C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00079"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACZ73268.1"
FT   NON_TER         301
FT                   /evidence="ECO:0000313|EMBL:ACZ73268.1"
SQ   SEQUENCE   301 AA;  34017 MW;  937DE0C1317E0E68 CRC64;
     FYGKADIAVA PLTITLVREE VIDFSKPFMS LGISIMIKKP QKSKPGVFSF LDPLAYEIWM
     CIVFAYIGVS VVLFLVSRFS PYEWHTEEYE DGQIQTNEST NEFGIFNSLW FSLGAFMRQG
     CDISPRSLSG RIVGGVWWFF TLIIISSYTA NLAAFLTVER MVSPIESAED LAKQTEIAYG
     TLDSGSTKEF FRRSKIALFD KMWTYMRSAE PSVFVKTTAE GVLRVRKSKG KYAYLLESTM
     NEYIEQRKPC DTMKVGGNLD SKGYGIATPK GSPLGNAVNL AVLKLNEQGL LDKLKNKWWY
     E
//
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