ID D2KBP8_HYDVU Unreviewed; 327 AA.
AC D2KBP8;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Myc proto-oncogene protein 2 {ECO:0000313|RefSeq:NP_001267863.1};
DE SubName: Full=Myc2 {ECO:0000313|EMBL:ADA57607.1};
GN Name=myc2 {ECO:0000313|RefSeq:NP_001267863.1};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:ADA57607.1};
RN [1] {ECO:0000313|EMBL:ADA57607.1, ECO:0000313|RefSeq:NP_001267863.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20142507; DOI=10.1073/pnas.0911060107;
RA Hartl M., Mitterstiller A.M., Valovka T., Breuker K., Hobmayer B.,
RA Bister K.;
RT "Stem cell-specific activation of an ancestral myc protooncogene with
RT conserved basic functions in the early metazoan Hydra.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:4051-4056(2010).
RN [2] {ECO:0000313|RefSeq:NP_001267863.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; GU199337; ADA57607.1; -; mRNA.
DR RefSeq; NP_001267863.1; NM_001280934.1.
DR EnsemblMetazoa; NM_001280934.1; NP_001267863.1; GeneID_100199110.
DR GeneID; 100199110; -.
DR KEGG; hmg:100199110; -.
DR CTD; 100199110; -.
DR OMA; STRKDCP; -.
DR OrthoDB; 3039999at2759; -.
DR Proteomes; UP000694840; Unplaced.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd11400; bHLHzip_Myc; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002418; Tscrpt_reg_Myc.
DR InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR PANTHER; PTHR45851:SF3; MYC PROTEIN; 1.
DR PANTHER; PTHR45851; MYC PROTO-ONCOGENE; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF01056; Myc_N; 1.
DR PIRSF; PIRSF001705; Myc_protein; 3.
DR PRINTS; PR00044; LEUZIPPRMYC.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000694840}.
FT DOMAIN 244..296
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT COILED 293..327
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 327 AA; 36935 MW; 59FC0477C9CCB671 CRC64;
MTGSNWCTHD ILPTDEILLH KSILDTSSPS DDVWKKFLTP PSSPQSIGES SESEETTDSF
DTCARLQYVC DNLDIGLELT TRCTNSFNLG SKLISDCMWS GVLPDLSKIQ SKEKFMCTRK
LTLDAEDLYP SPCPSPLSNM NSSTSVPDCP STSECVDPTA VFPLTSNNEF LFCPTDTDEE
IDVVTIDSKP INIVGLKRQS STSIVYTKIQ TTSVLKRTRS SPAKLRSDRL MRKSALIDDL
DPTSRRASHN VLERKRRIDL KRSFEKLREC VPNLEREEKA PKVVVLKKAL MYILALKTEE
KELTEQKRTL QKENEELNSK LKKILFK
//
