ID   D2PGA8_SULID            Unreviewed;       730 AA.
AC   D2PGA8;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Alpha-glucosidase {ECO:0000313|EMBL:ADB88248.1};
GN   OrderedLocusNames=LD85_2631 {ECO:0000313|EMBL:ADB88248.1};
OS   Sulfolobus islandicus (strain L.D.8.5 / Lassen #2).
OC   Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=425944 {ECO:0000313|EMBL:ADB88248.1, ECO:0000313|Proteomes:UP000001404};
RN   [1] {ECO:0000313|Proteomes:UP000001404}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L.D.8.5 / Lassen #2 {ECO:0000313|Proteomes:UP000001404};
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC       {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
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DR   EMBL; CP001731; ADB88248.1; -; Genomic_DNA.
DR   RefSeq; WP_012714361.1; NC_013769.1.
DR   AlphaFoldDB; D2PGA8; -.
DR   CAZy; GH31; Glycoside Hydrolase Family 31.
DR   GeneID; 8762474; -.
DR   KEGG; sii:LD85_2631; -.
DR   HOGENOM; CLU_000631_7_3_2; -.
DR   Proteomes; UP000001404; Chromosome.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd14752; GH31_N; 1.
DR   CDD; cd06591; GH31_xylosidase_XylS; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 2.
DR   InterPro; IPR033403; DUF5110.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR048395; Glyco_hydro_31_C.
DR   InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR   InterPro; IPR000322; Glyco_hydro_31_TIM.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR43863; HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED; 1.
DR   PANTHER; PTHR43863:SF2; MALTASE-GLUCOAMYLASE, INTESTINAL-LIKE; 1.
DR   Pfam; PF17137; DUF5110; 1.
DR   Pfam; PF13802; Gal_mutarotas_2; 1.
DR   Pfam; PF01055; Glyco_hydro_31_2nd; 1.
DR   Pfam; PF21365; Glyco_hydro_31_3rd; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|RuleBase:RU361185};
KW   Hydrolase {ECO:0000256|RuleBase:RU361185}.
FT   DOMAIN          8..169
FT                   /note="Glycoside hydrolase family 31 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13802"
FT   DOMAIN          215..527
FT                   /note="Glycoside hydrolase family 31 TIM barrel"
FT                   /evidence="ECO:0000259|Pfam:PF01055"
FT   DOMAIN          535..622
FT                   /note="Glycosyl hydrolase family 31 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21365"
FT   DOMAIN          639..693
FT                   /note="DUF5110"
FT                   /evidence="ECO:0000259|Pfam:PF17137"
SQ   SEQUENCE   730 AA;  84138 MW;  5337457F0F84918C CRC64;
     MRIGNFNVEI EFIADNILRV LYYYGREAVI DNSLVVLPNL EKLSIKGEST SPSIISLSSK
     SLSVDINTSN GELIIKDNKG GIVVKEKRRD LKFNEELSTY NVEQEFGLSE GERLYGLGQH
     AGGNGLGQSS AYKLDYNGLS ITLSQRNTDI GIPFIISSKG YGILWDNYSL GSISLKGNEL
     RVWFEAGKKI DYYVIFGDFI DDVIKGYRKL TGDAPLLPKW AYGYWQSKER YKSQDELVSV
     VKEFRERKIP LDVIVLDWRY WGKYGWNAFK FDEIDFPRPK DMVEEIHKMG AKLAISIWPT
     FGKETEVFKN MESKGCIIPG TTAVNPFKEG CRELFWSYVK RFYDIGIDAY WLDASEPETG
     LGLVFFSPIH DVDLGIGKGY EHLNAYPLME TKAVYEGQRR ISDKRVAILT RSAFAGQQRY
     SAISWSGDVL GDWATLRSQI PAGLNFSISG IPYWTTDTGG FFSGNPETKA YAEIFVRWFQ
     WSTFCPILRV HGTIFPKEPW RFPKEYQDVI LKYIRLRYEL LPYIYSLAWM TYSNGYTIMR
     PLVMDFRNDK NVYDLDEQYM FGPYIMVSPV TLPSIREKDV YLPSDEYWYD FWTGEKLEGG
     RTTDVKVSLG TIPLFVRGGA VLPLLGKDVS NAMEDWDVLH LRIYPGKDGY FEIYDDDGVT
     YDYERGKYFI VPIRWDDNKQ ELTIGKKRGD LEMRKRIMIT WVEKGKGIEY SKPDVEVEYD
     GKESITVKRH
//