ID D2PIV5_SULID Unreviewed; 657 AA.
AC D2PIV5;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase, NAD-binding protein {ECO:0000313|EMBL:ADB86708.1};
GN OrderedLocusNames=LD85_1016 {ECO:0000313|EMBL:ADB86708.1};
OS Sulfolobus islandicus (strain L.D.8.5 / Lassen #2).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=425944 {ECO:0000313|EMBL:ADB86708.1, ECO:0000313|Proteomes:UP000001404};
RN [1] {ECO:0000313|Proteomes:UP000001404}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L.D.8.5 / Lassen #2 {ECO:0000313|Proteomes:UP000001404};
RX PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT "Biogeography of the Sulfolobus islandicus pan-genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP001731; ADB86708.1; -; Genomic_DNA.
DR RefSeq; WP_012952642.1; NC_013769.1.
DR AlphaFoldDB; D2PIV5; -.
DR GeneID; 8760832; -.
DR KEGG; sii:LD85_1016; -.
DR HOGENOM; CLU_010448_2_1_2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000001404; Chromosome.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.12.10; Lyase 2-enoyl-coa Hydratase, Chain A, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857}.
FT DOMAIN 6..184
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 187..281
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 305..395
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 657 AA; 73472 MW; 055A348054FBAF04 CRC64;
MPIFSKVGVV GAGTMGHGIV EVAAISGYQV YLSDVSQDIL NNALEKIRWS LQKLKESGKL
KESIDTIISR IKPTTNLNDF ADADYIIEAV VENSEVKRKI FSELDGIVKP NAIFATNTST
IPISTLAEAT KRQDKFIGLH FMNPPVLMPL VEIIMGNKTS QQTLEITIEF AKSIGKDYVI
VKKDVPGFLI NRINGRTFAE AILMYDEGYQ KEDIDAMTRF RLGMPMGFLE LLDFTGIDVS
YNAALEAIKR GEKEPPHFKV LKKMVEEGRL GVKSGKGFYT YKSKIYERPK IVPTDSMYLI
NPLTIIAPAV NEAAWLIRNN ISSAEDIEKG MVKGMNWPQG PLTFADKFGI DNIVNFLEQR
YHDTGNDYYN PDSLLKEMVE QKKLGVKSGE GFFKWNYEKV DFGPVRYEKL HDYAKITMRR
AEKLNALNEA MWTGLTQAFN KAKEDKDVRA VIIMGEGRAF CAGDDIEMMH YWENTASVIE
WSQKISSPLI DTLTDYPKPI IAEVNGLAFG GGMELLILFD IVIASEDATF AIPEGLIGAL
PPLASSIGVG FISRKIARYA LTGEWLSAKQ AKELGLVDTV VPPEQLEITG VEIVEKVKRV
APLSSMSIKR AINSIRNSYL DNLQIASQEL TILSTTEDFK EGMKAFIERR QPRYKGK
//
