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Database: UniProt
Entry: D2PQE5_KRIFD
LinkDB: D2PQE5_KRIFD
Original site: D2PQE5_KRIFD 
ID   D2PQE5_KRIFD            Unreviewed;       604 AA.
AC   D2PQE5;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   25-OCT-2017, entry version 61.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Kfla_0001 {ECO:0000313|EMBL:ADB29132.1};
OS   Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Kribbella.
OX   NCBI_TaxID=479435 {ECO:0000313|EMBL:ADB29132.1, ECO:0000313|Proteomes:UP000007967};
RN   [1] {ECO:0000313|Proteomes:UP000007967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17836 / JCM 10339 / NBRC 14399
RC   {ECO:0000313|Proteomes:UP000007967};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Saunders E., Brettin T., Detter J.C., Han C., Larimer F.,
RA   Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA   Woyke T., Wu D., Pukall R., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Kribbella flavida DSM 17836.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001736; ADB29132.1; -; Genomic_DNA.
DR   RefSeq; WP_012917689.1; NC_013729.1.
DR   ProteinModelPortal; D2PQE5; -.
DR   STRING; 479435.Kfla_0001; -.
DR   EnsemblBacteria; ADB29132; ADB29132; Kfla_0001.
DR   KEGG; kfl:Kfla_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; QMSERRS; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000007967; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007967};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007967}.
FT   DOMAIN      295    423       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      507    576       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     303    310       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   604 AA;  67367 MW;  ACA39630C8CF392E CRC64;
     MAGDRDEVAP AGLTARPTGH RSDGFGEQRV VEDQSASAGG RAEVKDLDEA WTRVLAGLPP
     NQRAWLTNSR PVTLHESTAI VAVPDDFTRG QLETRLRPDL ERILSESFGR DIRIAVTVDP
     SLDPELREPA PQQPVQEPVR QSMPLHQPPQ YQQHQSGQLQ PSQQQQPAYG QPSPQRHDQY
     QQPAPTPQQP EQRSQHAQPS QPLQTEGSYQ PTIQSALSAP DAIGQHNHPL HQQVQQPLGS
     VAPPPNGSAP SQTATEAHGE ARLNPKYTFE TFVIGSSNRF AHAAAVAVAE APGKAYNPQL
     IYGDSGLGKT HLLHAIGHYV RSLYTGARVR YVSSEEFTND FINAIRDDKA SQFQRRYRDV
     DVLLIDDIQF LEGKIQTQEE FFHTFNTLHN ANKQIVISSD RAPKRLEALE DRLRNRFEWG
     LITDIQPPDL ETRIAILRKK AATERLTAPP EVLEFIASKV QTNIRELEGA LIRVTAFASL
     NRQPVDLSLA EIVLKDLIPE GSKPEVTASM IMGQTASYFG LSIDDLCGSS RSRVLVTARQ
     IAMYLCRELT DLSLPKIGQQ FGGRDHTTVM HAERKIRQLM SERRSVFNQV TELTNRIKHQ
     AKQQ
//
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