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Database: UniProt
Entry: D2Q6H8_BIFDB
LinkDB: D2Q6H8_BIFDB
Original site: D2Q6H8_BIFDB 
ID   D2Q6H8_BIFDB            Unreviewed;       500 AA.
AC   D2Q6H8;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   05-JUL-2017, entry version 59.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ADB08700.1};
GN   OrderedLocusNames=BDP_0001 {ECO:0000313|EMBL:ADB08700.1};
OS   Bifidobacterium dentium (strain ATCC 27534 / DSM 20436 / JCM 1195 /
OS   Bd1).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=401473 {ECO:0000313|EMBL:ADB08700.1, ECO:0000313|Proteomes:UP000008693};
RN   [1] {ECO:0000313|EMBL:ADB08700.1, ECO:0000313|Proteomes:UP000008693}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27534 / DSM 20436 / JCM 1195 / Bd1
RC   {ECO:0000313|Proteomes:UP000008693};
RX   PubMed=20041198; DOI=10.1371/journal.pgen.1000785;
RA   Ventura M., Turroni F., Zomer A., Foroni E., Giubellini V.,
RA   Bottacini F., Canchaya C., Claesson M.J., He F., Mantzourani M.,
RA   Mulas L., Ferrarini A., Gao B., Delledonne M., Henrissat B.,
RA   Coutinho P., Oggioni M., Gupta R.S., Zhang Z., Beighton D.,
RA   Fitzgerald G.F., O'Toole P.W., van Sinderen D.;
RT   "The Bifidobacterium dentium Bd1 genome sequence reflects its genetic
RT   adaptation to the human oral cavity.";
RL   PLoS Genet. 5:E1000785-E1000785(2009).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001750; ADB08700.1; -; Genomic_DNA.
DR   RefSeq; WP_012901761.1; NC_013714.1.
DR   ProteinModelPortal; D2Q6H8; -.
DR   STRING; 401473.BDP_0001; -.
DR   EnsemblBacteria; ADB08700; ADB08700; BDP_0001.
DR   GeneID; 31605239; -.
DR   KEGG; bde:BDP_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; VENWVKD; -.
DR   Proteomes; UP000008693; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008693};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008693}.
FT   DOMAIN      188    327       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      403    472       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     196    203       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   500 AA;  56241 MW;  43B6963C02F8DA4F CRC64;
     MVDTPHNPLD QARGVWSDAL ALLRQNPKLS ARDKGWLENV VPEGMWGPTI VLCVPSAATQ
     QALQTELNQP LMEALKDSAE QDIFPAFKIV PMQQTVEPDI EEYPHFDRKP RTQREESTQG
     QLPIPASMPE QPFRPTEQGT FTSGQNRPLL DPQTHLNKNA TFDTFVPGDS NRFARTVALA
     VAEGSGHDFN PLCIYGGSGL GKTHLLNAIG NYALVKDPNL KVRYVTSEEF TNEFIEALGD
     TNQNSGQIKE FNRRYREVDV LLIDDIQFLS GKEATLEQFF HTFNTLHQAN KRIVIASDVP
     PKDLKGFQAR LISRFESGLT VDVKPPDLET RIAILRMMAT MNGSNIPNDV LNLIAERFTE
     NIRELEGALN RVTAMASLSN QPVTRALAEH TLQDFFTSDV EIKPADIISQ VAKYFHLTFD
     DIVGRSRTKN IALARQVAMY LVRELTSMSL NDIGLVFGGK DHTTVMHAYT RISDEMQEKQ
     EIYNYVMELT VRLKQHSSEK
//
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