ID D2RN79_ACIFV Unreviewed; 762 AA.
AC D2RN79;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=Aconitate hydratase domain protein {ECO:0000313|EMBL:ADB46505.1};
GN OrderedLocusNames=Acfer_0096 {ECO:0000313|EMBL:ADB46505.1};
OS Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP
OS 106432 / VR4).
OC Bacteria; Bacillota; Negativicutes; Acidaminococcales; Acidaminococcaceae;
OC Acidaminococcus.
OX NCBI_TaxID=591001 {ECO:0000313|EMBL:ADB46505.1, ECO:0000313|Proteomes:UP000001902};
RN [1] {ECO:0000313|EMBL:ADB46505.1, ECO:0000313|Proteomes:UP000001902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4
RC {ECO:0000313|Proteomes:UP000001902};
RX PubMed=21304687; DOI=10.4056/sigs.1002553;
RA Chang Y.J., Pukall R., Saunders E., Lapidus A., Copeland A., Nolan M.,
RA Glavina Del Rio T., Lucas S., Chen F., Tice H., Cheng J.F., Han C.,
RA Detter J.C., Bruce D., Goodwin L., Pitluck S., Mikhailova N., Liolios K.,
RA Pati A., Ivanova N., Mavromatis K., Chen A., Palaniappan K., Land M.,
RA Hauser L., Jeffries C.D., Brettin T., Rohde M., Goker M., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Acidaminococcus fermentans type strain
RT (VR4).";
RL Stand. Genomic Sci. 3:1-14(2010).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC {ECO:0000256|ARBA:ARBA00007185}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001859; ADB46505.1; -; Genomic_DNA.
DR RefSeq; WP_012937496.1; NZ_CP085936.1.
DR AlphaFoldDB; D2RN79; -.
DR STRING; 591001.Acfer_0096; -.
DR GeneID; 78333847; -.
DR KEGG; afn:Acfer_0096; -.
DR eggNOG; COG1048; Bacteria.
DR HOGENOM; CLU_006714_2_3_9; -.
DR OrthoDB; 9764318at2; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000001902; Chromosome.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.1060.10; Aconitase, Domain 2; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR015932; Aconitase_dom2.
DR InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR PANTHER; PTHR43160; ACONITATE HYDRATASE B; 1.
DR PANTHER; PTHR43160:SF3; ACONITATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF00330; Aconitase; 1.
DR Pfam; PF00694; Aconitase_C; 1.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001902}.
FT DOMAIN 42..473
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 622..687
FT /note="Aconitase A/isopropylmalate dehydratase small
FT subunit swivel"
FT /evidence="ECO:0000259|Pfam:PF00694"
SQ SEQUENCE 762 AA; 83254 MW; FAE5EE51989C78E8 CRC64;
MVELIHEGVY YRDGQLLTEA ELAAQGVKAD RDGGTRKTLA YQVLKAHQQG EGMDDLHLKF
DALTSHDITY VGIIQTAIAS GLDHFPVPYI LTNCHNSLAA VGGTINEDDH VFGLSAVKRF
GGQYVPPHMA VIHEYMREKM AGGGKMILGS DSHTRYGAFG TMAIGEGGPE LVKQLLGHTY
DVQRPQVIAI YLKGKPRHGV GPQDVALAIE KAVFKNGFVK NKVMEFMGPG IAGLSMDFRN
GIDVMTTETT CLTTIWSTDT TVKDYLELHR RPEAYREMKP GDLAYYDGAV VVDLDKVESM
IAMPFHPSHV YTIKELNEGG RDLLEEIEKQ AVDMLDNKEL SLGLADKYYD GKMHCDQGLI
AGCSGGLYEN LVAAAHILKG RSIGNERFAF SVYPSSHPIY MELMRNGALA DLMDAGAVVR
SAFCGPCFGA GDTPNNKGFS VRHTTRNFPN REGSKPGKGQ IASVALMDAR SVAATAANHG
ALTPATEVEY DDSVPAYHYD SLPYDHKVFD GIGQPDKKEE LVYGPSIKPW PSIEKLNENV
LLKVAAWIDD PVTTTDELIP SGETSSYRSD PYALSEFALS RKVPEYVGRA KAVRTLEKAR
QEGENCEELN NMYDSVKNAL GLQESADQMK KNTSVGSVVY ANKPGDGSAR EQAASCQRVL
GGAANIALEY ATKRYRSNVM NWGMLPFLTS YDDSRKLAVG DLVYVPNVRE ILLGDTDEYK
GFIVRDGKKV GEIALHLGAV EPSQKEILAA GCLINYYAGS KK
//
