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Database: UniProt
Entry: D2SFL6_GEOOG
LinkDB: D2SFL6_GEOOG
Original site: D2SFL6_GEOOG 
ID   D2SFL6_GEOOG            Unreviewed;       584 AA.
AC   D2SFL6;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   05-JUL-2017, entry version 59.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Gobs_0001 {ECO:0000313|EMBL:ADB72813.1};
OS   Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 /
OS   G-20).
OC   Bacteria; Actinobacteria; Geodermatophilales; Geodermatophilaceae;
OC   Geodermatophilus.
OX   NCBI_TaxID=526225 {ECO:0000313|EMBL:ADB72813.1, ECO:0000313|Proteomes:UP000001382};
RN   [1] {ECO:0000313|Proteomes:UP000001382}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25078 / DSM 43160 / JCM 3152 / G-20
RC   {ECO:0000313|Proteomes:UP000001382};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Munk A.C., Brettin T., Detter J.C., Han C., Larimer F.,
RA   Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA   Woyke T., Wu D., Jando M., Schneider S., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Geodermatophilus obscurus DSM 43160.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001867; ADB72813.1; -; Genomic_DNA.
DR   RefSeq; WP_012946254.1; NC_013757.1.
DR   STRING; 526225.Gobs_0001; -.
DR   PRIDE; D2SFL6; -.
DR   EnsemblBacteria; ADB72813; ADB72813; Gobs_0001.
DR   KEGG; gob:Gobs_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; ATHIERN; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001382; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001382};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001382}.
FT   DOMAIN      276    404       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      488    557       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     284    291       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   584 AA;  64937 MW;  1532B315A5FA422D CRC64;
     MADATVDLAT VWDQIRERLA TSLSPQQNAM LNLTRPVGVF EDTAVLSAPN EFTQTVLESR
     MRRVLAEALS EHLGRDIRVA VQVEDSPAPP PAAPTPEVPT RRPWSVVEAQ RAQEDRETRD
     RTDDGRSAFG VRADVRPAWE DDGATTPDAR PAERDVDEWA PTDWSPPARR PAGRGTRAAD
     RDWGGTDLDE DGVAVLPFDL DAGDAPEPPA PPSRGRRGGS RGGGDAVPLF GDRRAPTGAQ
     DPGLNPKYVF DSFVIGNSNR FAHAAAVAVA EAPARAYNPL FIYGDSGLGK THLLHAIGHY
     AARMFPNVRV RYVSTEEFTN EFINLVHSGR AEDFRRRYRD IDFLLIDDIQ FLERAERTQE
     EFFHTFNTLH NASKQIVITS DRAPKKLTTL EDRLRTRFEW GLITDVQAPD LETRIAILRK
     KAYGERLQVP DPVLEFIASK VQTNIRELEG ALIRVTAFAS LNKQQVDLPL AELVLKDLIS
     DEQGPQITAA IIMAATAEYF SVTMEELQGS NRSRTLVNAR QIAMYLCREL TELSLPRIGA
     SFGGKDHTTV MHAVKKITNL MSERRATYTQ VTELTARIKS RARS
//
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