ID D2SWC8_ECOLX Unreviewed; 300 AA.
AC D2SWC8;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=FimH protein {ECO:0000313|EMBL:VFS35139.1};
DE SubName: Full=Type 1 fimbrial adhesin {ECO:0000313|EMBL:ACZ17663.1};
DE Flags: Fragment;
GN Name=fimH {ECO:0000313|EMBL:ACZ17663.1};
GN Synonyms=fimH_2 {ECO:0000313|EMBL:VFS35139.1};
GN ORFNames=NCTC9001_05069 {ECO:0000313|EMBL:VFS35139.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:ACZ17663.1};
RN [1] {ECO:0000313|EMBL:ACZ17663.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ECOR9 {ECO:0000313|EMBL:ACZ17887.1}, PY2
RC {ECO:0000313|EMBL:ACZ17886.1}, and TOP115
RC {ECO:0000313|EMBL:ACZ17663.1};
RX PubMed=20018753; DOI=10.1073/pnas.0902179106;
RA Chen S.L., Hung C.S., Pinkner J.S., Walker J.N., Cusumano C.K., Li Z.,
RA Bouckaert J., Gordon J.I., Hultgren S.J.;
RT "Positive selection identifies an in vivo role for FimH during urinary
RT tract infection in addition to mannose binding.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:22439-22444(2009).
RN [2] {ECO:0000313|EMBL:VFS35139.1, ECO:0000313|Proteomes:UP000372890}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC9001 {ECO:0000313|EMBL:VFS35139.1,
RC ECO:0000313|Proteomes:UP000372890};
RG Pathogen Informatics;
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000256|ARBA:ARBA00004561}.
CC -!- SIMILARITY: Belongs to the fimbrial protein family.
CC {ECO:0000256|ARBA:ARBA00006671}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FJ865612; ACZ17663.1; -; Genomic_DNA.
DR EMBL; FJ865835; ACZ17886.1; -; Genomic_DNA.
DR EMBL; FJ865836; ACZ17887.1; -; Genomic_DNA.
DR EMBL; CAADIS010000005; VFS35139.1; -; Genomic_DNA.
DR RefSeq; WP_001338195.1; NZ_WTOB01000029.1.
DR AlphaFoldDB; D2SWC8; -.
DR PATRIC; fig|562.6968.peg.3153; -.
DR Proteomes; UP000372890; Unassembled WGS sequence.
DR GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd10466; FimH_man-bind; 1.
DR Gene3D; 2.60.40.1090; Fimbrial-type adhesion domain; 2.
DR InterPro; IPR000259; Adhesion_dom_fimbrial.
DR InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR InterPro; IPR008966; Adhesion_dom_sf.
DR InterPro; IPR015243; FimH_man-bd.
DR PANTHER; PTHR33420; FIMBRIAL SUBUNIT ELFA-RELATED; 1.
DR PANTHER; PTHR33420:SF11; TYPE 1 FIMBRIN D-MANNOSE SPECIFIC ADHESIN; 1.
DR Pfam; PF00419; Fimbrial; 1.
DR Pfam; PF09160; FimH_man-bind; 1.
DR SUPFAM; SSF49401; Bacterial adhesins; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..300
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015088458"
FT DOMAIN 24..168
FT /note="FimH mannose-binding"
FT /evidence="ECO:0000259|Pfam:PF09160"
FT DOMAIN 178..300
FT /note="Fimbrial-type adhesion"
FT /evidence="ECO:0000259|Pfam:PF00419"
FT NON_TER 300
FT /evidence="ECO:0000313|EMBL:ACZ17663.1"
SQ SEQUENCE 300 AA; 31501 MW; 158ABC37835CD564 CRC64;
MKRVINLFAI LLMGWSVNAW SFACKTANGT AIPIGGGSAN VYVNLAPAVN VGQNLVVDLS
TQIFCHNDYP ETITDYVTLQ RGSAYGGVLS NFSGTVKYSG SSYPFPTTSE TPRVVYNSRT
DKPWPVALYL TPVSSAGGVV IKAGSLIAVL ILRQTNNYNS DDFQFVWNIY ANNDVVVPTG
GCDVSARDVT VTLPDYPGSV PIPLTVYCAK SQNLGYYLSG TTADAGNSIF TNTASFSPAQ
GVGVQLTRNG TIIPANNTVS LGAVGTSAVS LGLTANYART GGQVTAGNVQ SIIGVTFVYQ
//
