ID D2SWH5_ECOLX Unreviewed; 300 AA.
AC D2SWH5;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Fimbrial protein {ECO:0000313|EMBL:EAB7204024.1};
DE SubName: Full=Type 1 fimbria D-mannose specific adhesin FimH {ECO:0000313|EMBL:HAH7769366.1};
DE SubName: Full=Type 1 fimbrial adhesin {ECO:0000313|EMBL:ACZ17710.1};
DE Flags: Fragment;
GN Name=fimH {ECO:0000313|EMBL:ACZ17710.1};
GN ORFNames=D4U49_15945 {ECO:0000313|EMBL:EAB7204024.1}, D9J61_11125
GN {ECO:0000313|EMBL:EAC1532568.1}, G3W53_03020
GN {ECO:0000313|EMBL:NEN69182.1}, GP711_08175
GN {ECO:0000313|EMBL:KAE9732670.1}, GQN34_17540
GN {ECO:0000313|EMBL:MWP25855.1}, HIE29_002817
GN {ECO:0000313|EMBL:HAH7769366.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:ACZ17710.1};
RN [1] {ECO:0000313|EMBL:ACZ17710.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ECOR66 {ECO:0000313|EMBL:ACZ17710.1}, TOP2205
RC {ECO:0000313|EMBL:ACZ17821.1}, and TOP2653
RC {ECO:0000313|EMBL:ACZ17763.1};
RX PubMed=20018753; DOI=10.1073/pnas.0902179106;
RA Chen S.L., Hung C.S., Pinkner J.S., Walker J.N., Cusumano C.K., Li Z.,
RA Bouckaert J., Gordon J.I., Hultgren S.J.;
RT "Positive selection identifies an in vivo role for FimH during urinary
RT tract infection in addition to mannose binding.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:22439-22444(2009).
RN [2] {ECO:0000313|EMBL:HAH7769366.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C0382 {ECO:0000313|EMBL:HAH7769366.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [3] {ECO:0000313|EMBL:EAB7204024.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=587367 {ECO:0000313|EMBL:EAB7204024.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:EAC1532568.1, ECO:0000313|Proteomes:UP000382540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CVM N17EC1330 {ECO:0000313|EMBL:EAC1532568.1,
RC ECO:0000313|Proteomes:UP000382540};
RG NARMS: The National Antimicrobial Resistance Monitoring System;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:KAE9732670.1, ECO:0000313|Proteomes:UP000437875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TzEc067 {ECO:0000313|EMBL:KAE9732670.1,
RC ECO:0000313|Proteomes:UP000437875};
RA Subbiah M., Call D.R.;
RT "Antimicrobial-resistant enteric bacteria are widely distributed amongst
RT people, animals and the environment in northern Tanzania.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:MWP25855.1, ECO:0000313|Proteomes:UP000438259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10433wD12 {ECO:0000313|EMBL:MWP25855.1,
RC ECO:0000313|Proteomes:UP000438259};
RA Subbiah M., Call D.;
RT "Enteriobacteria Tanzani isolates_10433.";
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:HAH7769366.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C0382 {ECO:0000313|EMBL:HAH7769366.1};
RG NCBI Pathogen Detection Project;
RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:NEN69182.1, ECO:0000313|Proteomes:UP000471360}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=8375wB1 {ECO:0000313|EMBL:NEN69182.1,
RC ECO:0000313|Proteomes:UP000471360};
RA Subbiah M., Call D.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000256|ARBA:ARBA00004561}.
CC -!- SIMILARITY: Belongs to the fimbrial protein family.
CC {ECO:0000256|ARBA:ARBA00006671}.
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DR EMBL; FJ865659; ACZ17710.1; -; Genomic_DNA.
DR EMBL; FJ865712; ACZ17763.1; -; Genomic_DNA.
DR EMBL; FJ865770; ACZ17821.1; -; Genomic_DNA.
DR EMBL; AAAFOP010000047; EAB7204024.1; -; Genomic_DNA.
DR EMBL; AAAGZE010000022; EAC1532568.1; -; Genomic_DNA.
DR EMBL; DABCJL010000006; HAH7769366.1; -; Genomic_DNA.
DR EMBL; WSGM01000004; KAE9732670.1; -; Genomic_DNA.
DR EMBL; WTOC01000007; MWP25855.1; -; Genomic_DNA.
DR EMBL; JAAGYP010000003; NEN69182.1; -; Genomic_DNA.
DR RefSeq; WP_001531278.1; NZ_WTPD01000006.1.
DR AlphaFoldDB; D2SWH5; -.
DR Proteomes; UP000382540; Unassembled WGS sequence.
DR Proteomes; UP000437875; Unassembled WGS sequence.
DR Proteomes; UP000438259; Unassembled WGS sequence.
DR Proteomes; UP000471360; Unassembled WGS sequence.
DR Proteomes; UP000843571; Unassembled WGS sequence.
DR GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd10466; FimH_man-bind; 1.
DR Gene3D; 2.60.40.1090; Fimbrial-type adhesion domain; 2.
DR InterPro; IPR000259; Adhesion_dom_fimbrial.
DR InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR InterPro; IPR008966; Adhesion_dom_sf.
DR InterPro; IPR015243; FimH_man-bd.
DR PANTHER; PTHR33420; FIMBRIAL SUBUNIT ELFA-RELATED; 1.
DR PANTHER; PTHR33420:SF11; TYPE 1 FIMBRIN D-MANNOSE SPECIFIC ADHESIN; 1.
DR Pfam; PF00419; Fimbrial; 1.
DR Pfam; PF09160; FimH_man-bind; 1.
DR SUPFAM; SSF49401; Bacterial adhesins; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..300
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015088461"
FT DOMAIN 24..168
FT /note="FimH mannose-binding"
FT /evidence="ECO:0000259|Pfam:PF09160"
FT DOMAIN 178..300
FT /note="Fimbrial-type adhesion"
FT /evidence="ECO:0000259|Pfam:PF00419"
FT NON_TER 300
FT /evidence="ECO:0000313|EMBL:ACZ17710.1"
SQ SEQUENCE 300 AA; 31501 MW; 90DCDDB3F5284D8A CRC64;
MKRVITLFAV LLMGWSVNAW SFACKTANGT AIPIGGGSAN VYVNLAPAVN VGQNLVVDLS
TQIFCHNDYP ETITDYVTLQ RGSAYGGVLS NFSGTVKYNG SSYPFPTTSE TPRVVYNSRT
DKPWPVALYL TPVSSAGGVA IKAGSLIAVL ILRQTNNYNS DDFQFVWNIY ANNDVVVPTG
GCDVSARDVT VTLPDYPGSV PIPLTVYCAK SQNLGYYLSG TTADAGNSIF TNTASFSPAQ
GVGVQLTRNG TIIPANNTVS LGVVGTSAVS LGLTANYART GGQVTAGNVQ SIIGVTFVYQ
//
