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Database: UniProt
Entry: D2TM02_CITRI
LinkDB: D2TM02_CITRI
Original site: D2TM02_CITRI 
ID   D2TM02_CITRI            Unreviewed;       244 AA.
AC   D2TM02;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   05-JUL-2017, entry version 45.
DE   RecName: Full=Flagellar brake protein YcgR {ECO:0000256|HAMAP-Rule:MF_01457};
DE   AltName: Full=Cyclic di-GMP binding protein YcgR {ECO:0000256|HAMAP-Rule:MF_01457};
GN   Name=ycgR {ECO:0000256|HAMAP-Rule:MF_01457};
GN   OrderedLocusNames=ROD_18241 {ECO:0000313|EMBL:CBG88579.1};
OS   Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype
OS   4280).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=637910 {ECO:0000313|EMBL:CBG88579.1, ECO:0000313|Proteomes:UP000001889};
RN   [1] {ECO:0000313|EMBL:CBG88579.1, ECO:0000313|Proteomes:UP000001889}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ICC168 {ECO:0000313|EMBL:CBG88579.1,
RC   ECO:0000313|Proteomes:UP000001889};
RX   PubMed=19897651; DOI=10.1128/JB.01144-09;
RA   Petty N.K., Bulgin R., Crepin V.F., Cerdeno-Tarraga A.M.,
RA   Schroeder G.N., Quail M.A., Lennard N., Corton C., Barron A.,
RA   Clark L., Toribio A.L., Parkhill J., Dougan G., Frankel G.,
RA   Thomson N.R.;
RT   "The Citrobacter rodentium genome sequence reveals convergent
RT   evolution with human pathogenic Escherichia coli.";
RL   J. Bacteriol. 192:525-538(2010).
CC   -!- FUNCTION: Acts as a flagellar brake, regulating swimming and
CC       swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-
CC       dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing
CC       levels of c-di-GMP lead to decreased motility. {ECO:0000256|HAMAP-
CC       Rule:MF_01457}.
CC   -!- SUBUNIT: Monomer. Interacts with the flagellar basal bodies.
CC       {ECO:0000256|HAMAP-Rule:MF_01457}.
CC   -!- SUBCELLULAR LOCATION: Bacterial flagellum basal body
CC       {ECO:0000256|HAMAP-Rule:MF_01457}.
CC   -!- SIMILARITY: Belongs to the YcgR family. {ECO:0000256|HAMAP-
CC       Rule:MF_01457}.
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DR   EMBL; FN543502; CBG88579.1; -; Genomic_DNA.
DR   RefSeq; WP_012906061.1; NC_013716.1.
DR   ProteinModelPortal; D2TM02; -.
DR   STRING; 637910.ROD_18241; -.
DR   EnsemblBacteria; CBG88579; CBG88579; ROD_18241.
DR   KEGG; cro:ROD_18241; -.
DR   eggNOG; ENOG4108T7K; Bacteria.
DR   eggNOG; COG5581; LUCA.
DR   HOGENOM; HOG000265609; -.
DR   KO; K21087; -.
DR   OMA; YVQRREY; -.
DR   OrthoDB; POG091H0NAE; -.
DR   Proteomes; UP000001889; Chromosome.
DR   GO; GO:0009425; C:bacterial-type flagellum basal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0035438; F:cyclic-di-GMP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IEA:UniProtKB-HAMAP.
DR   GO; GO:0071945; P:regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed; IEA:UniProtKB-HAMAP.
DR   Gene3D; 2.30.110.10; -; 1.
DR   HAMAP; MF_01457; YcgR; 1.
DR   InterPro; IPR009875; PilZ_domain.
DR   InterPro; IPR012349; Split_barrel_FMN-bd.
DR   InterPro; IPR023787; T3SS_YcgR.
DR   InterPro; IPR009926; T3SS_YcgR_N.
DR   Pfam; PF07238; PilZ; 1.
DR   Pfam; PF07317; YcgR; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum {ECO:0000256|HAMAP-Rule:MF_01457};
KW   c-di-GMP {ECO:0000256|HAMAP-Rule:MF_01457};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001889};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01457};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001889}.
FT   DOMAIN        8    109       T3SS_YcgR_N. {ECO:0000259|Pfam:PF07317}.
FT   DOMAIN      112    230       PilZ. {ECO:0000259|Pfam:PF07238}.
SQ   SEQUENCE   244 AA;  27795 MW;  D8EA1D6ADF92863B CRC64;
     MSHYHQQFLK QHPLAVLGVL RDLHREQVPL RLAWSGGQFI SKILAVSAER LVMDFGSQQQ
     DNRAVQQARQ ITITAETQGA KVEFTVEQLQ RDDYQQLPAF ITPLPSALWF VQRREYFRIS
     APLHPPYCCV ATLPDNSTLR FRLYDLSLGG MGALMEGATP EGLTEGMRFS QIALEMGKWG
     QFHVDAQLIA ITERKVIGGK NETVSTPRLS FRFLNVSPAV ERELQRIIFS LEREAREKAS
     RVRD
//
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