ID   D2U5B2_ECHMU            Unreviewed;       489 AA.
AC   D2U5B2;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=phosphoenolpyruvate carboxykinase (GTP) {ECO:0000256|ARBA:ARBA00012306};
DE            EC=4.1.1.32 {ECO:0000256|ARBA:ARBA00012306};
DE   Flags: Fragment;
GN   Name=pepck {ECO:0000313|EMBL:CBH36485.1};
OS   Echinococcus multilocularis (Fox tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX   NCBI_TaxID=6211 {ECO:0000313|EMBL:CBH36485.1};
RN   [1] {ECO:0000313|EMBL:CBH36485.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Knapp J., Nakao M., Yanagida T., Okamoto M., Saarma U., Lavikainen A.,
RA   Ito A.;
RT   "Phylogenetic relationships within Echinococcus and Taenia tapeworms
RT   (Cestoda: Taeniidae): An inference from nuclear protein-coding genes.";
RL   Mol. Phylogenet. Evol. 61:628-638(2011).
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP]
CC       family. {ECO:0000256|ARBA:ARBA00005796}.
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DR   EMBL; FN567985; CBH36485.1; -; Genomic_DNA.
DR   AlphaFoldDB; D2U5B2; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043648; P:dicarboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00819; PEPCK_GTP; 1.
DR   Gene3D; 3.90.228.20; -; 1.
DR   Gene3D; 3.40.449.10; Phosphoenolpyruvate Carboxykinase, domain 1; 1.
DR   Gene3D; 2.170.8.10; Phosphoenolpyruvate Carboxykinase, domain 2; 1.
DR   HAMAP; MF_00452; PEPCK_GTP; 1.
DR   InterPro; IPR018091; PEP_carboxykin_GTP_CS.
DR   InterPro; IPR013035; PEP_carboxykinase_C.
DR   InterPro; IPR008209; PEP_carboxykinase_GTP.
DR   InterPro; IPR035077; PEP_carboxykinase_GTP_C.
DR   InterPro; IPR035078; PEP_carboxykinase_GTP_N.
DR   InterPro; IPR008210; PEP_carboxykinase_N.
DR   PANTHER; PTHR11561; PHOSPHOENOLPYRUVATE CARBOXYKINASE; 1.
DR   PANTHER; PTHR11561:SF0; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP)-RELATED; 1.
DR   Pfam; PF00821; PEPCK_GTP; 1.
DR   Pfam; PF17297; PEPCK_N; 1.
DR   SUPFAM; SSF68923; PEP carboxykinase N-terminal domain; 1.
DR   SUPFAM; SSF53795; PEP carboxykinase-like; 1.
DR   PROSITE; PS00505; PEPCK_GTP; 1.
PE   3: Inferred from homology;
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Kinase {ECO:0000313|EMBL:CBH36485.1};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Pyruvate {ECO:0000313|EMBL:CBH36485.1};
KW   Transferase {ECO:0000313|EMBL:CBH36485.1}.
FT   DOMAIN          1..211
FT                   /note="Phosphoenolpyruvate carboxykinase GTP-utilising N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17297"
FT   DOMAIN          216..489
FT                   /note="Phosphoenolpyruvate carboxykinase C-terminal P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF00821"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CBH36485.1"
FT   NON_TER         489
FT                   /evidence="ECO:0000313|EMBL:CBH36485.1"
SQ   SEQUENCE   489 AA;  54701 MW;  AD80EDD732F36A85 CRC64;
     GSKAEADKIT DELLKSGTLR RLAAYENNFI CCTDPKDVAR VESKTFICTP DRFQTVPHVA
     EGVKGILGQW ISPKDLDESL RDRFPGCMND RTLYVIPFSM GPIGSPLAKY GIQITDSQYV
     VLCMRIMTRM SLKVLDYIKE QNTFVRCLHS IGLPLPHEGV KVINNWPCNP EKTIISHIPD
     DRLIMSFGSG YGGNSLLGKK CFALRIASRI AYDEGWMAEH MLIMSVTNPK GEEKFVCAAF
     PSACGKTNMA MLTPSLPGWK VMCVGDDIAW MRFNDKGELR AINPEAGFFG VAPGTNHKTN
     PNALECCMKN SVLTNVAETD DGRFFWEGLE SEYKPETKLT TWLGEKTTVG AKTATPKAHP
     NSRFCCPASQ CPIIHPKWED PAGVPVSVFM FGGRRPEGIP LVYEARTWKH GVMIGAQVKS
     EATAAAEFKG RQVMHDPMAM RPFMGYNFGK YLEHWLSMEK PGRHMPRIFH VNWFRLDSHG
     RFAWPGFGN
//