ID D2V0Y2_NAEGR Unreviewed; 1833 AA.
AC D2V0Y2;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC49596.1};
GN ORFNames=NAEGRDRAFT_62456 {ECO:0000313|EMBL:EFC49596.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC49596.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC49596.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG738847; EFC49596.1; -; Genomic_DNA.
DR RefSeq; XP_002682340.1; XM_002682294.1.
DR STRING; 5762.D2V0Y2; -.
DR EnsemblProtists; EFC49596; EFC49596; NAEGRDRAFT_62456.
DR GeneID; 8855480; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_62456; -.
DR eggNOG; KOG1820; Eukaryota.
DR InParanoid; D2V0Y2; -.
DR OMA; VCEYVRE; -.
DR OrthoDB; 5479337at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0099080; C:supramolecular complex; IEA:UniProt.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR019399; Parkin_co-regulated_protein.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF10274; ParcG; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 170..391
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 418..654
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 725..961
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 977..1214
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1641..1664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1213..1237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1274..1298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1833 AA; 205740 MW; 5E221C3466DC959D CRC64;
MLEEELRKEE ERMKNKSQKP KISSNNSDKL LRPPSASTSL NPPPANISPT ASVELSNFLI
SSKNINNFIS DAPPVNIPTE ENNNSEISSP TSETIKTSSS TVKEEKNSKP STPASDIKVG
TVPKKQNPIN KPSPQNELNK SIPIPENNLN GDSASSSQDS TTLFETLLKE ELERSKQQSE
GGEDKPAWAK KVDELDELIT KFKTKDTNDS IFQDSETELT QTLNNRHPNI LEKGVETLFH
YVNRYQNVQN SAEKFINLLV DKGLSSKSSV QQKSTDIILL YFETCDPAAI LTVLKAFFSS
KKAKVRSQCI GIVKSAVQCF GFPTIPPKMI LQSLPTILED ASSREESHKL AIETFKWLGY
ETVEPHLKDV KGSKLKALKD EYDLLQDKSP KPTRFSRLAS VYNSTASIKN LVTAASEELK
AKREIIDLND KIRKDWYDDV TNAKWIIKRD ALKELKQLLE TFNIKKADYS EILSQINVII
QREKNVVVVK ESIECLSAFS KALKTDFTSS AKPFYERLLT KLKEKNLSDS TIECLVSFDV
SSFPFTDMLE TIFSAMNNKT ASTSEKLQIF TFIDKCFQNK KKKDLEKALK NLVNNLLSFC
EDASSEVRDL CCKTLARLLF IIGDTDYTNL FLKLDSYMKE KIVQYLESYG SPPSDGVGKK
LSQSIEKKTA PANIPKTTSS VTLRPSSRAD TNPVRSSTSS LAKKPSSKPL VSKSISLKKT
ESIQSLSSSD VIEEANNLFG GNIVEQLANS NWNDRMLSLN HIESVISSLD KNDLQTKHEH
IISLFQYKPG TKESNAKVLE KIFEIIERVL SSTEGKLSEV NIPPTLQWMI EKLATPKVDI
IIQKAMKKVC ESINPQFVFN KISETLTDKM PPKLIGSVLE WLGEVITEFS IACFNSSELI
EFSKKYLGNS NPIIKKGCIK MLCSMKLFMG EGLLNFLGDV KPALLDMVKK DFSKVDSKPP
EPTRKVKGEQ LKVSSAMYDT LPRCDILPKL HPKIYHSMED KNWMTRLEAI QTVEKIIVND
AHKRILPNIL ELIHALRQRL EDNNNKVVIS TLLLIDLISE AVGPEMEKFI KILLPSVISK
SMHNNKAVRT CALESLEKYL NIVQFESMLK IFPKSIASDK GNPEGKKEII EFMHKHIVEM
KNKNVDLFTP LVKPILDYLT KAGSDTRKLA EAILGEIISN GGYDFVFKRI RELKAAHQKG
FSLLLQKYAP STEVESQPPP VTQSLTLPTT PSNSIRGDKK ITLRDVSKSL SVDTRQTEEE
EGSKVPKTVK KRANISKTLA TSPNKSPSPS SPKTKPITNT FVPKLQFSTG ITGIATVDEY
KLDLDKIEVN HDSPVEAETP MHDVYNSANG PMPGNITPRM PERSPVRDNK KEELISGHSI
GELVKAINTN DHGSEIAINA LKTLVSMFKD ESCRPAILSY LKELVESLTD NTQYSFEKAS
AGLVSTRICK YLLSTLMQLF SNRQMAAFVP QETLQRMIDQ LLSRLLDERL PSLDYGQELL
RGLNSLMLKV LENSNRTYSY TSLIHLLEYS YANTSLKKYT ELVVKCLIKL TKALAATIDR
VDVDILLMDL HSFLTHNPPT FFKDRNDLPL RTIKTILNEL VKVKGETIRS CLGLIPTHKN
PLIISYIELM VNSAQTTVSS STNSQATVPS TTTPNITAQT ISKPPRNSVT ASQIQQAYPL
QQPSTVSNEK IVQDELTDIF NLISNKDSTH TGLYRLYEFK KNHPSVGINN HLLKCSEPFQ
QYIHRQLAKI AQYESSKQES FAASSHRAQS PASRQRQATA ITSVDDIRRQ LKLHQQESKQ
KNMGRSLTVS DLKKRIQNIE EKLSSTDNET TEE
//
