ID D2V147_NAEGR Unreviewed; 1826 AA.
AC D2V147;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Myosin {ECO:0000313|EMBL:EFC49629.1};
GN ORFNames=NAEGRDRAFT_78120 {ECO:0000313|EMBL:EFC49629.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC49629.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC49629.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; GG738847; EFC49629.1; -; Genomic_DNA.
DR RefSeq; XP_002682373.1; XM_002682327.1.
DR SMR; D2V147; -.
DR STRING; 5762.D2V147; -.
DR EnsemblProtists; EFC49629; EFC49629; NAEGRDRAFT_78120.
DR GeneID; 8856442; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_78120; -.
DR eggNOG; KOG0162; Eukaryota.
DR InParanoid; D2V147; -.
DR OrthoDB; 5476192at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd00124; MYSc; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF679; UNCONVENTIONAL MYOSIN IC; 1.
DR Pfam; PF00063; Myosin_head; 3.
DR Pfam; PF06017; Myosin_TH1; 4.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 4.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 19..841
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 847..1053
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT DOMAIN 1066..1250
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT DOMAIN 1297..1480
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT DOMAIN 1526..1703
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 108..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 176..183
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1826 AA; 209927 MW; 10AB3662DBEE21D0 CRC64;
MCDDLTLLLS QSSMKSKKSE QMVVPQKTEI TEIDLTNILA NRYYQNEIYT CVGPAILSIN
PYKAVKGLYS NETKALFHSH IPYELAPHIY SLAEDAYRTL LEHATANKPT STHVTRARPA
ITAVSSSSAH SKKMPPPPPP GKPINKEADL DDDTFIINDF SISDGIGVGQ AIIIQGESGS
GKTLASRIIM EYLAAVSISG LETQRIKDSI LQSNPLLESF GNAKTLRNNN SSRFGKFTNL
YFNFKGQLMG GELTTILLEK ARVVKRRLGE RNFHIFYQLL SDDYIRKQLN LGFPEEYNYL
NNNVININEV DDKSEFETTK RAMDLLDMSV PEQMAVFKIV AAILQLGNIT FTAIEDPEER
KRRNIAPGVE ACDVSNEASL KLVANTLQID AEFLRRSMII RVIKTVGSPM PIEQTQSVEQ
AEFNRDTLAK NIYERLFLWL VKRVNRALRV PDYEDFVAKK NSETYYNIGI LDIYGFEIYD
KNIGTGKIVD QDEASNQGKL KNGFEQLCIN FVNEKIQSGV QRSIKKEQED IQKEIYGDDF
KPTLASTQER NKRFDSDAAI QMIAGKPISV FSLLDEESMF PNGNDVNYVQ KMKTNIKHPY
FKIPRIAEPT EFELEHFAAL VKYNTADGWV DKNRDTLLAE MLYTMQNTKD HLLMALFPKN
EQANDVLSKK PANAGTKLQQ TTAEKFLRDV SKLMNQLSSC SLKHHHIRCI IPNYEGRADD
FQKDVVNHQV RYLGILDTVL SRKADDLGSN VTGYSIKIPY DTFLERYKLL CPETFPYWET
FITNKYGPVE EFTIEHKKEA VHQILSQEHI GMTNPQDFFL GRGNVLLASP VQLFQLDEMI
REQKHEMARK IQNSFRRYRK KRAGKMEEMM KKAIKTTEPT KQKEAPEEIR IRHDGFRTSN
FGETKKRVLI TGSDRRNIFL LDTTSSSSEF EQLRKIAIRD IKKIYISPYS DNYMIFKLDM
DEGDELVELD NKWEFLEEFN KLIESTASNF KGEHVPRVEV TKDISILNHQ KDKNTGTQNL
LVRFIPSAYN TKKTVTTECY ADEFDNRLFI VNTFTQADIY NQRKLRRKAS LYAKQDQNRD
YLRMQNSELM QLLKKDYDDS KVLFSGVVSK YNKRFKKQDR IFMVTDKAIY NIDPSGGYLI
NRRVPIGQVT SVTVSPYTDN FFVVDHPDQD ILSESAKKTE ILESILESFQ NATNQLLPVK
VTTNYYINLA KKNTKRVAIS WIIEPENQTQ FSVSTLVPNT AGGADVHVVS EVDNDNDKSM
NDLAVRQSFQ RRSVRGKMVK NGDMDEVDLN DVFGGLKVRR KDSLLVWFQG DYLNFKDNPK
FIEMVKKHDP EWNGQVLFSN LMTKVNKRFR TQPRKVVVTP NYIYTLDDEK LHFNRITPIK
DLSGISLSTM RDAFFVVHCP TDHDLFASCK KKTELVSVIC DAFKDKTGMD LPVHVEDKFV
YKPSTDVKGV KTIEFRHDPT TKVPILTPTK LGCLIQVNNS DPEKVKQNLP TAKQQKPAAT
PQLKLYEGSD ERGIQDKMDS IYTGRKGRNR RSLLREYLGD YLRLEGTQRM KKVFDRNGDT
ELIFSGQVLK YNKNFKKQHR LLVVTDKNVY NIDEQEFKIK RKIPLEEITG VSVSPFDDNV
FVMHCPTSGD YLLEDEKKTE IISALQNARL RHLKQPLKIN VDDQFNFAPN SSSTMPVTFI
SDDHCKDTWA ENRANALVVH VKRQEPGVVL EAAYLYLNEE SKPIEVKSTP ILIKLKKRWT
YKLQIRFYVN EYLAGCEFHE KIDTVSSRLE FVSKVVELEP KEERYVITLP ERKVIYSLLS
KTRVKCKLVD PSGKVLMAVR FVYDIQ
//
