ID D2V1X4_NAEGR Unreviewed; 657 AA.
AC D2V1X4;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Guanine nucleotide binding protein alpha subunit {ECO:0000313|EMBL:EFC49387.1};
GN ORFNames=NAEGRDRAFT_78188 {ECO:0000313|EMBL:EFC49387.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC49387.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC49387.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SIMILARITY: Belongs to the G-alpha family.
CC {ECO:0000256|ARBA:ARBA00005804}.
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DR EMBL; GG738848; EFC49387.1; -; Genomic_DNA.
DR RefSeq; XP_002682131.1; XM_002682085.1.
DR AlphaFoldDB; D2V1X4; -.
DR STRING; 5762.D2V1X4; -.
DR EnsemblProtists; EFC49387; EFC49387; NAEGRDRAFT_78188.
DR GeneID; 8852604; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_78188; -.
DR eggNOG; KOG0082; Eukaryota.
DR InParanoid; D2V1X4; -.
DR OrthoDB; 1221906at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF302; GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-8 SUBUNIT-RELATED; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 127..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 75070 MW; A05CCA773A8AE9BB CRC64;
MESLLSFFFP SITSVIRESN EHERMKKEMM NRYLKKKKAF GDVPPGQQQQ HKLEPNMMIP
MANQATATVT TQENNGHESD SETTATQQLY KKLKSTIGQN QIIPLSTVPF DKPIPLYMSG
DEVVNSNETT TASSSLTSPS PSVTSNLSTT TTTPMMMSNL STTTPTTTPS TLSTAVNHHQ
QSSSSTTTTI DIHDVSPANT NNQLYHLSNH ISKNMNVTTN GHFSSNAPSH RKEMNKATSS
NAQHVAKTKK VQKSKYESPS VYTLMLSGTL GSGKTTLFRQ FRLVFQEGFN RSEIERMRMY
IITNLLQSFS LGVSLYLNEV DAIKNGTTKV TRENRFMLDE TLYEKFKEFD SRVTSLQSRY
TLFDISKLPQ KEFVVSMWED TDVRKVLNRY ALTDSMTDGM DYYLRDHGDT SAVKRMFKKL
SEYEPSVEDI IGCRCKTTGI TCLDYDYLGM PFRVYDVGGA RTERKKYNNI YAGLTGVLYT
TSLIDFRKTC YEDDFSNRMI ESINLFEEQC NGPLKYSPIF LIFTKIDILS ETISDDKSLF
DLFPDFNQYP VPDQNNFFTN TSSQLNPNNN PQRYLLDKEV QISQKVLKTL SFIESKFKAK
DNHNPKRIFT FYMNALDTIQ FKQLMEIITS TIYPMFAHNQ TKPNLSWKFK THILGNE
//
