ID D2V2W3_NAEGR Unreviewed; 297 AA.
AC D2V2W3;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Protein AF-9 homolog {ECO:0000256|ARBA:ARBA00022408};
GN ORFNames=NAEGRDRAFT_63139 {ECO:0000313|EMBL:EFC49131.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC49131.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC49131.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC transcriptional regulation of selected genes by chromatin remodeling.
CC Component of the NuA4 histone acetyltransferase complex which is
CC involved in transcriptional activation of selected genes principally by
CC acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Yaf9 may also be required for viability in
CC conditions in which the structural integrity of the spindle is
CC compromised. {ECO:0000256|ARBA:ARBA00025636}.
CC -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex and of the
CC NuA4 histone acetyltransferase complex.
CC {ECO:0000256|ARBA:ARBA00038745}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|PROSITE-ProRule:PRU00376}.
CC -!- SIMILARITY: Belongs to the YAF9 family.
CC {ECO:0000256|ARBA:ARBA00038419}.
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DR EMBL; GG738849; EFC49131.1; -; Genomic_DNA.
DR RefSeq; XP_002681875.1; XM_002681829.1.
DR AlphaFoldDB; D2V2W3; -.
DR STRING; 5762.D2V2W3; -.
DR EnsemblProtists; EFC49131; EFC49131; NAEGRDRAFT_63139.
DR GeneID; 8855121; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_63139; -.
DR eggNOG; KOG3149; Eukaryota.
DR eggNOG; KOG4159; Eukaryota.
DR InParanoid; D2V2W3; -.
DR OMA; VRTQCNH; -.
DR OrthoDB; 180572at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd16514; RING-HC_LONFs_rpt2; 1.
DR CDD; cd16887; YEATS; 1.
DR Gene3D; 2.60.40.1970; YEATS domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR038704; YEAST_sf.
DR InterPro; IPR005033; YEATS.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23195; YEATS DOMAIN; 1.
DR PANTHER; PTHR23195:SF15; YEATS DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF03366; YEATS; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51037; YEATS; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00376}; Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 50..91
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 297 AA; 34107 MW; E9BC833740DE0DCD CRC64;
MFINNNNNSL NPLTTTTTSR QQTSTGNNTT PINSSNNNNN SNPVISDFEC PLCLNLLYEP
VGFHCGHTFC KFCIERLLAS NGSMNACPCC RAPFSDGNNS LITLKNIRPL LTLRNVLPML
FKEQYEMRRL EVEKERREYV QTQTIRKSFF IGNEHTVISR SDQNIHKWTM FVRMDSRENV
SDFIHSVEYR LHPTFKPNVV VVDKAPFELT RFGWGYFTVK VKITFQSYLN KPAFATNHTL
SFDGNGLMSQ VEIDFLVKRE QQSEIYIDII NSPTSEEDMS GEGMSSNNMF DDDEDVL
//
