ID D2V595_NAEGR Unreviewed; 637 AA.
AC D2V595;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC48235.1};
GN ORFNames=NAEGRDRAFT_46814 {ECO:0000313|EMBL:EFC48235.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC48235.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC48235.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738852; EFC48235.1; -; Genomic_DNA.
DR RefSeq; XP_002680979.1; XM_002680933.1.
DR AlphaFoldDB; D2V595; -.
DR STRING; 5762.D2V595; -.
DR EnsemblProtists; EFC48235; EFC48235; NAEGRDRAFT_46814.
DR GeneID; 8861474; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_46814; -.
DR eggNOG; KOG0800; Eukaryota.
DR InParanoid; D2V595; -.
DR OrthoDB; 103025at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45931:SF3; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45931; SI:CH211-59O9.10; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..637
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003037263"
FT TRANSMEM 210..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 589..632
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 468..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 637 AA; 71697 MW; 78808129714EF2F9 CRC64;
MKASLLFLLA LTATLMISEF IVCDVNFGAG KRNGETFKTI QVTDKLLELE LIPDKDGDIF
TLQRKDLLDI CSTVITMEFK DKSSTDLPSS INNLVATSRT NDIPSSGSYK MLVPKGMKYT
GTVHVAAGGK LKIKTSEGNF FTFEVGLLSL LGQDKPVSLV APSNIDELFT ITLTSETSKC
YLDGYLESTT SSDTPSRNVK EATPPDATGI AIGVIIGIIA CCCLSCIAIA ALVIYTTKRG
NKGGPSGGIT VVTTGATGTT VVNEMNSISN KKKTNKTIMI NGFSNKDDQN IIEVAELVTL
KMSKSSEEIL FEDFNDQTNC STYSSLSNNS NSTNTSEWGD VMDLEEELFN ASEDFEYQVI
KFEYPFNAEY EDIFNNQLEE LIDEDEEGFE EAEEEEYNNN LYEEYFEEYE YNHCLGGMKF
KHLANMKKVK QKFKRMRINP KRRIHHRELK KQQEEVIEKR EKVSSKIYTP PPIRYADNNY
SNNNNNRHHQ HGSNSDEEAQ LQQAISHSLT DHHVNDYARE CGIEYNLLLA LTQRELTAED
YDLLLQLDNT VKKKTVSENI LDSLPCCTLN HFGEVCQSDM PQITEGDMCI TCMCDFEEGD
EVRWITKCAH IFHKNCIDNW LNNHSTCCPI CRVEVNS
//
