ID D2V9E7_NAEGR Unreviewed; 442 AA.
AC D2V9E7;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC46448.1};
GN ORFNames=NAEGRDRAFT_65415 {ECO:0000313|EMBL:EFC46448.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC46448.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC46448.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SIMILARITY: Belongs to the G-alpha family.
CC {ECO:0000256|ARBA:ARBA00005804}.
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DR EMBL; GG738858; EFC46448.1; -; Genomic_DNA.
DR RefSeq; XP_002679192.1; XM_002679146.1.
DR AlphaFoldDB; D2V9E7; -.
DR STRING; 5762.D2V9E7; -.
DR EnsemblProtists; EFC46448; EFC46448; NAEGRDRAFT_65415.
DR GeneID; 8851219; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_65415; -.
DR eggNOG; KOG0082; Eukaryota.
DR InParanoid; D2V9E7; -.
DR OrthoDB; 5522971at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF302; GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-8 SUBUNIT-RELATED; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 99..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 49984 MW; C9CD726390DDC8F7 CRC64;
MLRSTGDRSE VDLDEMLEQD QAKILLFGSG DSGKTTLLKQ IHGMTFSKYY NPTRLVGSIV
QDILKNVRLV CERCIEGGQI SQEEFSQCDY IIQIAKSTNS TSTPKKSTST TQDSPLPSSP
INTPDKRSSY GANASSPVGG GGHGASPGSG AGSPSRMNNL VSKMDDDLPD KILRLLNHSE
IFRKTVESCR ENERLSDGIE HFLLNSSNLR RVCEFNYVPS IADIVYSRQK TVGLIETSIR
YHEVDGFPKK EIHNFNDLEK QFPRTLKLVD TGGQSSERRK YKNVSFSSVR ACVFVVNMSG
FTKSLYENEN VNDLIDSIEL FKELFNQPFY ENVPILLLFN KMDMFSYQIQ KGKDLSSLFP
EFDNNATILE EKVDNSLKFL FKKYKDTLNS NPIRVQYMPT ALTDLKDAQK VFERVMELSE
LLTCPERNNE MTSNDKKKCT IM
//
