ID D2V9G9_NAEGR Unreviewed; 1739 AA.
AC D2V9G9;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Ankyrin repeat domain-containing protein {ECO:0000313|EMBL:EFC46590.1};
GN ORFNames=NAEGRDRAFT_79069 {ECO:0000313|EMBL:EFC46590.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC46590.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC46590.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738858; EFC46590.1; -; Genomic_DNA.
DR RefSeq; XP_002679334.1; XM_002679288.1.
DR STRING; 5762.D2V9G9; -.
DR EnsemblProtists; EFC46590; EFC46590; NAEGRDRAFT_79069.
DR GeneID; 8848670; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_79069; -.
DR eggNOG; KOG4177; Eukaryota.
DR eggNOG; KOG4412; Eukaryota.
DR InParanoid; D2V9G9; -.
DR OrthoDB; 2543462at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR CDD; cd09917; F-box_SF; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR PANTHER; PTHR24178:SF9; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR SMART; SM00248; ANK; 13.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF81383; F-box domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT REPEAT 931..963
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1386..1418
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1612..1644
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1670..1739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1698..1720
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1721..1739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1739 AA; 193308 MW; BDBF113DEDF4E332 CRC64;
MFNQPMSSPP QHSPTNNNNV FNNNNNNGTV VPDGSVGGAA MTSNVALNPT TNLQVVNGST
SNNSLVTIPT NSSSSTTMNV NGGAANLSAF NIPNIPSSAT ASTLSNIPTT IGNNNNQVGD
NISQFMLSTT KSVLSSMSSP TMSSNNQNAP LLPSPSSIQG LLHNSINSNI NALNNNVSQT
TLGGISQLLN PTTVNFNQQT SHQISIPSMN TANQNFTSQL NNNVGVVDQQ SNQWMNFNQS
SNNYQTQNPS SVLSMNQNPQ LNVVNNANSG LVNNLLNNQQ QTTNIELFNM LLASNGSNMN
SSIDMNNNIY NNNSNVNTMF NNGLIPTNNI NPMNNINISN NIPNSPPMNN SWKSMENPVL
SPNSYNRQNQ FTNQNFVNQQ IPSMNISNNN MSKFNQPNNL NNQNMFGSYN MNNMNSMNNM
SMNMNNSMNR GMGQQIQFQN VQFPPVNNNL REIVFEQSGY AKKRRDSSTP SASTTPSKKS
NTSKKEKPTP QAKTPKTPKT AQTKTPQTKE KPIAKPSVPS SRIDILKPLP DRIIYYILHF
LPSFPDYGSF CQVSKRFSEI CQVAYLQLDT LYLKKVSGVS NAKGAINRFY SMREDYIEDV
DVISVRRQLV SKENDPNKRK SKLDNLKVEK KDVTKLVLNQ VNVDNFKKLF ENSYLSESLK
DFTLIGQRFN SNSLKQFFTS LPKEVESVTL IGCLFTIDLP FAYYASLRKD ISPKMEILFS
EIVVVGAASN DEKSRKNKKK KLEEENPNPF IPTWMTVQEL KDSVTVDTLK KIQNLGLDLL
TDSICDGISG ACAACRYGDI DCVNYVLRLI NAESISPSVN MIYQTLLFNR KNLLPIINKF
VEIFPRNLLL SARFTTAQQK QSKSKPTTSE KLNYSFQSLL RVDQSPSELP TISKQSIEDR
QLTPYLCACA FGSLEICTLI SPEPVLQIDT DSNTGLHLAC MNGNIQVAKY LIEKNHSLDA
KNNKSQSILH SLMLCPPEKD SDDLTICLQM VLDRLAQRGN LTGILSARDL LGNTCLHYAV
ENRHSGGVKL LLDYYSKGDY VENYLKIANA KEMTPILLVF FNNAPRNDKT ANILISLMNN
NFENNFKELI IRKDEDGDVI SSKTIFTEIL ESESSFSTSF LNQYLSVMPE KKDSILNYSP
DSSSASLIYY CVSLPKDTTL LVKWLIANGA NVQQLDSSGK TFLHVAIEKE SIEDLDSVID
SLSLILSAEQ LKQLIMTQDK EKKYTVLHQC AISDKYAKSC AKLISVGADP LALDAEKNTP
LMVSISFANY DASQYLLTNE SKNFVNGNNV SPIILLLRNS KDLKHFLNEK EINQADYNTS
IEKLEELAMK MLESGVDIAS DTILDYVDED RPSALMLAIE GGLSMEIITK IVEHPDVFIN
HQTAKSLVTP LHVACEEGYS EVVTLLIQKG ANILMPDNNK AIPIVYAIIH SNSEAIELIL
QHIDSSCKIR KEAPNAEKLL ERAKFFIRDL PVECLESFML QAVSENILVD LLNRILSLRM
EQRNTSIEKD RDYKIFTDQG ASVLMVASQE GKLEVFKSYL EYMSTFETFN GGEFSEISEI
LKLGDQSNDT LAHYACMAPD NNKSTAAVIK EKLAILEILL KYSASLDIQN DEGNTPLHIA
CREGFTPLAK FLLKQGCDKN VTNNDGNTPD TLADDGGHYD LLAACFDEEV PEKPAKTKTS
NRNKRGTKRK SSSESDDEFV ASDQDADSDE ESDEDSEMSD DEAPTKTIPK RATKIKREM
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