ID D2VKE9_NAEGR Unreviewed; 1251 AA.
AC D2VKE9;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Type IIB DNA topoisomerase {ECO:0000313|EMBL:EFC42675.1};
GN ORFNames=NAEGRDRAFT_50278 {ECO:0000313|EMBL:EFC42675.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC42675.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC42675.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the TOP6A family.
CC {ECO:0000256|ARBA:ARBA00006559}.
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DR EMBL; GG738878; EFC42675.1; -; Genomic_DNA.
DR AlphaFoldDB; D2VKE9; -.
DR STRING; 5762.D2VKE9; -.
DR EnsemblProtists; EFC42675; EFC42675; NAEGRDRAFT_50278.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_50278; -.
DR eggNOG; KOG2795; Eukaryota.
DR InParanoid; D2VKE9; -.
DR OrthoDB; 3015043at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006259; P:DNA metabolic process; IEA:InterPro.
DR CDD; cd00223; TOPRIM_TopoIIB_SPO; 1.
DR Gene3D; 3.40.1360.10; -; 1.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002815; Spo11/TopoVI_A.
DR InterPro; IPR013049; Spo11/TopoVI_A_N.
DR InterPro; IPR036078; Spo11/TopoVI_A_sf.
DR InterPro; IPR034136; TOPRIM_Topo6A/Spo11.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR33099; FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR33099:SF13; FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF21180; TOP6A-Spo11_Toprim; 1.
DR Pfam; PF04406; TP6A_N; 1.
DR PRINTS; PR01550; TOP6AFAMILY.
DR SUPFAM; SSF56726; DNA topoisomerase IV, alpha subunit; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:EFC42675.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 51..106
FT /note="Spo11/DNA topoisomerase VI subunit A N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04406"
FT REGION 1203..1251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1251 AA; 143573 MW; 6808D79BFEEF2EEC CRC64;
METIQVRERI EEKVLAFVRE LVSSPSSDIP NEKGFLLKDL TKYPSTFISK FQVMNLVYQL
CTLNKFSTKR DLYYCNKPIL KDQTQLDSIL KDLSSSWRVN RHDLHIVPQS KGEVCGPIAW
KEISLIDIEN RGQQPTTTIV SASKGCNLPS IPHLQIVEFS IPVEVDKVII VEKESVFQVL
KSQASSLKDT SLIITSKGYP DVPTRDFIVT LTKQVAKYQR RSLNIFTLTD GDPYGAEIAN
VYMNGSLSFE NEKENLTIHS CVDSTEDWHY WVLQTCSRMS WIGVHLNDFD NAPQLISKWK
DCWMPLEELD LKKINSLNNT QLELDDTVKT QINLQKDLNY KVEIEESSET DSDYCEAYGS
DFYDDCVQLH ADTIKTSDNL QEFILDAQNK GGSKFTQCGA LDSDFGLPGL QLKLDNEQFK
TIGFPLSNGS ASELIQFCSK APYGRGEDTI YDENVRKTWQ LDPSRFEITN PTWDDLIDGL
VDNEIRDGLG ISKHLRLSAN LYKLLVYEEG GHFQFHKDSE KEERMFGTLV VQLPSEYSGG
EIIVRHGEEE EEYDFASVSR YTPHFISFYA DCEHMIKNVN SGYRVCLIYN LCFSGNKESK
PTLKGYEELA KRLQQIVSEW NADAKDVDTL YRMYVFQHQY SQKSLDPENL KGSDYNIYDI
LERYAEEYQD LVLDLGIMER KVEGFDDPEV SLEYIFGSQQ RKIDVPFRSV VCKSALSSMK
LFHKSINENT GNEGSTKEKQ YRNACLMIYP KKCQQRICLK FGFSFCSKIL PSFIESNSRE
NSIAFVKQML AKKNIYLWGD EEKVVIQSII QLNDVELAKL VIGIDQKSLS SLISHFTIEP
FRETISENLC KKRYMKEFIG SLIEINDVPL IQMTMPKYSV NKYDHLYDSS CFEKLIILAQ
KCTYSMHSTV VENIVEDYYK YASYKESITK LIDLLKDTSI YEKLIVKELA KNSIPNQRGR
GSYENKELDL PLIIKIANQI GVEKLKNLRF SFSKWLTSEN CLNMVLSTMS CKPLSELLIE
WMLYDHRDCF LDLKFATSFI RMLHNHSWND FITRACRVVL SVASEENYST LVAPLIEVVS
NIMPKSDQLD ILLNWSIDLI DDGIRTKKFI IPLPNFSVKS SISCICSDCK ILKQFLWSET
ERTCSITGLV KELSHIESMV APIREIQKQR VQKSIILTKL VISERLVKQA TELNNAAKTK
LESLLKKRRT PPEESTDNNS TLQLEVAPSS SIEPPNKKSK TDAPEIICID D
//