ID D2VMD1_NAEGR Unreviewed; 1342 AA.
AC D2VMD1;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC42042.1};
GN ORFNames=NAEGRDRAFT_80526 {ECO:0000313|EMBL:EFC42042.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC42042.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC42042.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SIMILARITY: Belongs to the WD repeat RAPTOR family.
CC {ECO:0000256|ARBA:ARBA00009257}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG738882; EFC42042.1; -; Genomic_DNA.
DR STRING; 5762.D2VMD1; -.
DR EnsemblProtists; EFC42042; EFC42042; NAEGRDRAFT_80526.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_80526; -.
DR eggNOG; KOG1517; Eukaryota.
DR InParanoid; D2VMD1; -.
DR OMA; EVKTFNV; -.
DR OrthoDB; 103066at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR004083; Raptor.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12848; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR PANTHER; PTHR12848:SF16; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR Pfam; PF14538; Raptor_N; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR01547; YEAST176DUF.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 143..295
FT /note="Raptor N-terminal CASPase-like"
FT /evidence="ECO:0000259|SMART:SM01302"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..37
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1342 AA; 152679 MW; B13ACA030F8C1D77 CRC64;
MIPNDYEENS RRRTNQDDDN DDIDNDEPNN QQQNDDEENF ENEPKYAQSG RSTLGGDYYD
DGYSQNNQGL STPSMNNVSP SSNTSISPPF GQSSDGLASF RLTKSRRRKS TNLPNKPLFF
TSDRHQVFTP VPREVIDWRM KQRLKTVHVA LVVCLNIGVD PPDVVKVQPC AKLECWVDPQ
THPQKALEAI GSNLKLQYER WQPRARYKQC LDPTVEDVKK TCVQLRKSAK KERILFHYNG
HGVPKPTTNG EIWVFNKTFT QYIPLSLYDL YCWMDSPSIY VFDCSNAGII LNSFIQIIEQ
KDAPPRGSVM KKENIILAAC GVKENLPMNP EYPADLFTSC LTTPIKIALR WFRQRNKLVS
GVTDDLIENI PGRINDRRTP LGELNWIFTA VTDTIAWNVL PRDLFHKLFR QDLLVASLFR
NFLLADRIMR SANCTPVSYP KLPETHNHPM WDAWDLALDQ CVSQLPNLFN NPSAEYQYNP
FFSAQLTDFQ VWLEFGHRIQ KPPTQLPILL QVLLSQSHRL RALTLLGRFL DMGSWAVNLA
LSVGIFPYVL KLLQSNSVEL RRILVFIWTK ILALDKPCQI DLVKDHGHSY FINVLVERNN
DTELRAMSCF VLSVIADRFN PGQQACLKYK NLFDLCSSQL TEQDPILRKW ACLLIAKLVE
DFDEGQELAI KSTTHEKVLR LLNDDVPEVR AASIFTLQKF VGNKPEKSEE RVQGEIKICT
ALYQTILDGS PMVRKELVYA LGTFIQQYGE FIAPELLKSI IKEETHYLNN APTPILVSGS
NSSSPNTLIF QQKKKKKKER KPVDEVTTQP STPKDARVLK DMKDRELGQL SYFALDVCRV
AIMLCFDPVR EVAEEAHKIL SFMRYTYSKL NDEDFERELF LIKEKAFNNT QNTPKSPAKP
MQKRLIDKLS MRRSASDSDF LKAGFVNQQS NYSDEDTDSD SLDVTSSSNS NMIFMKSNFY
ERSCEYFSNP ILTENSPKDD SFVSQQVLKR RKRNEHLVKE ANTMLKVAGK KKLEEQIGFF
GNESEICSQM KFHGFEPYLV VSDENDGLSV WNWVRGAIVN QFRCGDILKS RITDFHIINE
EAEQSMLLVA SAAGNVAIYK NYEKKEEPVS SFRAAHEALS SDSGLGILTE WQQHNGTLYV
TGDIEKVKIW DVDKEYCVQN IPLDVPVTSI AADPNNGYLF AAGCSDGKVL LFDKRESPNS
GPVLTHQLIS NYEEVSKNWV VSAKIQNVNS NQVITGYSSG DIMFWDTRVT NKCTRQFNAH
KGSMTALAIH NYAPVLACGS NNQFIKVFNT SGETLSMIYY HDGFLGQRIG PISCLAFHPF
RMCLAAGSTD SIISLYSGDT KK
//