ID D2VNU6_NAEGR Unreviewed; 563 AA.
AC D2VNU6;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC41478.1};
GN ORFNames=NAEGRDRAFT_70623 {ECO:0000313|EMBL:EFC41478.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC41478.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC41478.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR EMBL; GG738885; EFC41478.1; -; Genomic_DNA.
DR RefSeq; XP_002674222.1; XM_002674176.1.
DR AlphaFoldDB; D2VNU6; -.
DR EnsemblProtists; EFC41478; EFC41478; NAEGRDRAFT_70623.
DR GeneID; 8862427; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_70623; -.
DR eggNOG; KOG1479; Eukaryota.
DR InParanoid; D2VNU6; -.
DR OMA; FNIMDWV; -.
DR OrthoDB; 239997at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002259; Eqnu_transpt.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR Pfam; PF01733; Nucleoside_tran; 2.
DR PRINTS; PR01130; DERENTRNSPRT.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 142..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 470..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 25..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 64024 MW; 5BB56CE0BA7BA097 CRC64;
MISSVPPPQP SATVAVEDLH HQPRTKFTNQ GNNELPHHHH QHDGMVDDEE ESVMIRYHDR
QNNFGISGKL IHDRDDDQQG VGGSDHMKNN IEFQNVELSS NNNGKVIMER KEKEILSDHG
NRIDSQQQEV VNNSSLEPKD KYHMITIIFF IQGMGELFPW NAMLSAVDYL LALYSEQKVM
LWMTSVYSLI TLVTLLLLIK FGTHIRYRYR IYIPYVILIG LLIAVPLLYV IIGNRLAEFI
ILMAIVSVMA VCTGSIQSSV YGISSKLPHH YMNTVVSGSA FAGLFISLLR ILTKVTIESG
YEEVPIEILS TSTIIYFSFC AALNVVCIAT FIILERSPFV QYYLNQKVED QADANRDHAE
ITSIKNILTN IFKNVWINCL TIFLNFFVSL TIFPGLSSAI PSIYVGTSME TWLPIWSNLT
FQIYDFLGRI AYYWIDILPS GKFIPIESLP PTTSKYELFK RKLRVSTQEI ILLVLVLMRF
ILIPLFIFCL NPMLFKHDAI PLIFMFVMSL SNGYFNSILM SSAPKKFVNL HEKEITATTM
TFFLLLGISV GSNFGLILGL ILL
//
