ID D2VPU3_NAEGR Unreviewed; 708 AA.
AC D2VPU3;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=TNF receptor-associated protein {ECO:0000313|EMBL:EFC41267.1};
GN ORFNames=NAEGRDRAFT_58871 {ECO:0000313|EMBL:EFC41267.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC41267.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC41267.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC {ECO:0000256|ARBA:ARBA00008239}.
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DR EMBL; GG738887; EFC41267.1; -; Genomic_DNA.
DR AlphaFoldDB; D2VPU3; -.
DR STRING; 5762.D2VPU3; -.
DR EnsemblProtists; EFC41267; EFC41267; NAEGRDRAFT_58871.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_58871; -.
DR eggNOG; KOG0019; Eukaryota.
DR InParanoid; D2VPU3; -.
DR OMA; DHTQQNE; -.
DR OrthoDB; 5485387at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR CDD; cd16927; HATPase_Hsp90-like; 1.
DR Gene3D; 3.30.230.80; -; 1.
DR Gene3D; 3.40.50.11260; -; 1.
DR Gene3D; 1.20.120.790; Heat shock protein 90, C-terminal domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR HAMAP; MF_00505; HSP90; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR037196; HSP90_C.
DR InterPro; IPR001404; Hsp90_fam.
DR InterPro; IPR020575; Hsp90_N.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11528:SF44; HEAT SHOCK PROTEIN 75 KDA, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00183; HSP90; 1.
DR PIRSF; PIRSF002583; Hsp90; 1.
DR PRINTS; PR00775; HEATSHOCK90.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF110942; HSP90 C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000313|EMBL:EFC41267.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 119..279
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
SQ SEQUENCE 708 AA; 80282 MW; A2953C4BF3D29634 CRC64;
MLSRNSGKIV RSLVSKRSAA VRCSSSALPS SSSVLSKNSC SSYQQQQQLI ANFSSQLFVR
NEKKDVIDDD VFEDAEVNEL KEENIIRETE HIVGAKENKT FETETKQLLH IVASALYTDK
EVFIRELISN ASDALEKVRR MNQVSPDKVD DPSKELSVQI SCDDKNNIFV IQDSGIGMSK
EELIKNIGTI AHSGSRAFVK QLKEASDKGE ATSNIIGQFG VGFYSTFMVA DKVRIYTRSA
IKGQPGYCWE STGEGNYTIS EAEGVARGTK IVIYLKKNEK EFSFKDTVQK IIQKYSNFVS
YPIILNGAKV NTLDAVWLKS KNSVTAEEHQ EFYKYLSHYG GNPLYILHFN LDIPLNMNAL
FYVPDHHTES LGMGKMEPGV NVHSRRVLIR AKHPDILPDW LRFLKGVVDS EDLPLNISRE
HLQDSPLIQK IKSVLVKRIT KFFNDMMKQD REKYISFYEK FNKFIKEGVV TDYMYKDEAA
KLLMYESSAL PKGEKTTLEE YINRMGTEQK TIYYLIAPTR EYAENSPYFE VFKKKGIEVL
FGYDGPDDFV FGSIGYFNGK ETKAIDRAEL EDDEADKTSG ENELSEIQSK ELCEWFQTSL
KDKVSSAKIS KRLSTTPAVI KNPENASLRM IRKLQNQDIA LSPQQVEINP RHPLIMKLFN
AKSANPDLAK LVAEQIFDNA LISAGLLDDP RSMVNRLQNL MESSLKSF
//