ID D2VQ43_NAEGR Unreviewed; 1235 AA.
AC D2VQ43;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC41119.1};
GN ORFNames=NAEGRDRAFT_58918 {ECO:0000313|EMBL:EFC41119.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC41119.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC41119.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738888; EFC41119.1; -; Genomic_DNA.
DR RefSeq; XP_002673863.1; XM_002673817.1.
DR AlphaFoldDB; D2VQ43; -.
DR EnsemblProtists; EFC41119; EFC41119; NAEGRDRAFT_58918.
DR GeneID; 8851074; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_58918; -.
DR InParanoid; D2VQ43; -.
DR OrthoDB; 3134470at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR CDD; cd09917; F-box_SF; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR PANTHER; PTHR16146; INTELECTIN; 1.
DR Pfam; PF07974; EGF_2; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR PROSITE; PS00022; EGF_1; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 162..173
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS00022"
SQ SEQUENCE 1235 AA; 141326 MW; D2A3CAE144FCEFA3 CRC64;
MFCPASRKKT IISRRKAVAL LLLSLVILAT CLLGGNVVHS SPTTTKCTNT ESEGCGLRGY
IKDKQKEEDI LSCSIAKISK GIEFLKQAND TKLLEQIAQR EHQLRVKESA RSMLSSEISI
LSAQCSTYLG ENCDIPVECY GVPANSPTVC SGHGTCISSN NCLCFTSFSG SSCSNMSTIN
DPILGRTFAD GTTATSCYGY RYPTLPYAYN GEGSGLYQIN VGPTIYTAYC DMESMGGGWT
LIMKTSTSSP FVYDHAMWTA NDLSFLGTQK LPFTNITANE DYISPLFYKL AGRESRLAMN
SLENYNSWSH SYDTARNLIA NNGMMKSYAT NMSTSTCEPQ TNCGTQPINK KPLGIWRSLP
YDYKAAYWYR FGYINALGED SFGSKIRVGF SSDGDTSDTV DGRIGIGIDC LTMCGSYDGK
PHDELQKKMI NKLPPENLHH IFSYLDYFRD IFRLRKLAVL DFTNVRGWEI DDFNEVMDLE
YSDDGLSEYN SWEPLCITCK SFYEAFVSFQ PMEIKLQMIN GDKKNWARYP IDRSYFESLT
LIRSVQNLYT EECLQDNNYV HKVLERIKTR YENVFDRVVY VSCFAPFGKN YWTKRGGNIP
LKKIFKNVKY LVSNYPLVQS TISCIYEQNL FMESGGLAPR SIGANFPTEM EEIEYLKKAS
KLMGKRPFHV EIILAYSIYF QRIDTCKFII NNIDIDIGYF EHYWNIVLSI FSGGLSNNIL
DILCLIYLKY PEFKIFIVKG IVLEQLKILD KYPFIKFDVK RCILFPTDEI SESELVNRFS
KIGKYCFSYL GLTSCFDTLD NPDVFGVTPL MQKNQDKPMT LQQIMMKDIY GNNFLHYFFT
NNRNSSNYFT YSDTQFSKNI PNDILYKLEQ EENNFGLTPV EIAVANEWNH FKFQPLTKIF
HFKSIEKLIN GIRSFKLLDG FEVDLAILYA VAGVINPTID YSIYQDIDYR DRNGKHLIHY
FTKFDYLDIQ NVLPNLSAEE ILLTPDHNGT FLLHSCTNLY RDLLSSIAEW NESPTINISG
YFDNLGFNRI MYFLLKSKDE RHLKSDANVI GFDYSTENHP KLIHITILNK DNSIHFKLES
SNIPRITGGF QWYGGEEGDD ISHFLIRLCT QQILSKTHYA LEDVMSILIA RGLKFDIVKN
SRGKTALDLL NEFKENYPNI HTPLYKQVTR GTTKKSLALE EFVIKPSKCS VEEIISQSNS
LLVVKKSFIV ERNEVTLHRN LFFAQNRKRD VVDTL
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