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Database: UniProt
Entry: D2VRP1_NAEGR
LinkDB: D2VRP1_NAEGR
Original site: D2VRP1_NAEGR 
ID   D2VRP1_NAEGR            Unreviewed;       842 AA.
AC   D2VRP1;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   07-JUN-2017, entry version 34.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=NAEGRDRAFT_59034 {ECO:0000313|EMBL:EFC40495.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Heterolobosea; Schizopyrenida; Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC40495.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC40495.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B.,
RA   Carpenter M.L., Field M.C., Kuo A., Paredez A., Chapman J., Pham J.,
RA   Shu S., Neupane R., Cipriano M., Mancuso J., Tu H., Salamov A.,
RA   Lindquist E., Shapiro H., Lucas S., Grigoriev I.V., Cande W.Z.,
RA   Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GG738892; EFC40495.1; -; Genomic_DNA.
DR   STRING; 5762.XP_002673239.1; -.
DR   EnsemblProtists; EFC40495; EFC40495; NAEGRDRAFT_59034.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; D2VRP1; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006671};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    398    431       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    452    469       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    524    545       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    557    577       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    632    655       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    774    800       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      108    142       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   842 AA;  95173 MW;  C8A21DC83EE49568 CRC64;
     MATSHLIAGT KGSSMWRSEN MVLLEMTMQR EAAHQTVERL GELGYVEFKD LSSHLNAFQR
     QFANEVKRCE ELDRIIRFFE DQIEKSEVKF SEGADFNDEE TNEYGNVLDS FERDFSQHEK
     ELRDLSGNLD QMVAEKNKAE EYSYVLNLAA QFFKGDEESY SGDSESGLMV SRGSSLGYLT
     GVIPREKIST FLMLIYRSTR GNVVPRMVEI PTPLFDAKSG KSIEKSVFTV FFGASSAKEK
     VKKVCEALGA SIHDFPEDDV AGAQRSVQQK INELDTTIES SKLRVVDILS KISVNLPRWK
     ERVHKEKAIF HTLNLFNYDI KGSVVAVGWA AEKNFENVKR EMEEARLASN AQVPSICDIV
     QPTETPPTYF ETNKFTDVFQ QIVNSYGIPD YKEMNPAVAA VILFPFLFAV MFGDFGHGIL
     LAAAAIAMVV FEKKLKPIAE NSELLAMVFQ GRYILVLMGL FSIYTGFLYN DGLGLAVDIF
     PSAYEFNSEH VGEKIGRTYP FGVDPAWFHT SNKLLFYNSI KMKMSVIFGV GHMSIGLFFA
     LANMIQFGHF LDIFVEFIPE VLILWCTFGY MCVLIVYKWC VNWGDEVHSG KFDPPQILPM
     MTDYFLSPWK MSQPPMFYYG GDVAEAQARQ SYAQMALLLI TAISVPILLI PKPIAEYLKQ
     KRKFKHRKVD DAEVVNSNSD ESHHVAILDG TDGHDNVAHT HGEGHAEMEP FSELFIKQLI
     HTIEYVLGTV SNTASYLRLW ALSLAHAQLA EVFWQMTIGL ILNQLESMPE VETAVVHSGV
     GVFFVFALWF GMTIGVLLVM ESLSAFLHAL RLTWVEFQNK FFKGTGSLFR PFSFETFGKN
     DD
//
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