ID   D2VSK5_NAEGR            Unreviewed;      1000 AA.
AC   D2VSK5;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN   ORFNames=NAEGRDRAFT_59108 {ECO:0000313|EMBL:EFC40207.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC40207.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC40207.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; GG738894; EFC40207.1; -; Genomic_DNA.
DR   RefSeq; XP_002672951.1; XM_002672905.1.
DR   AlphaFoldDB; D2VSK5; -.
DR   STRING; 5762.D2VSK5; -.
DR   EnsemblProtists; EFC40207; EFC40207; NAEGRDRAFT_59108.
DR   GeneID; 8854682; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_59108; -.
DR   eggNOG; KOG1225; Eukaryota.
DR   InParanoid; D2VSK5; -.
DR   OMA; CANVECA; -.
DR   OrthoDB; 5471657at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.25.10; Laminin; 9.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   PANTHER; PTHR11219:SF69; TENEURIN-M; 1.
DR   Pfam; PF07974; EGF_2; 1.
DR   SMART; SM00181; EGF; 12.
DR   SUPFAM; SSF101898; NHL repeat; 1.
DR   PROSITE; PS00022; EGF_1; 6.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 4.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..1000
FT                   /note="EGF-like domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003038365"
FT   TRANSMEM        947..977
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          300..339
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          420..459
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          500..539
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          688..727
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DISULFID        329..338
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        449..458
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        529..538
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        717..726
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   1000 AA;  107374 MW;  F67EDC321DA79377 CRC64;
     MLNNNKWVVI NSIVLIFSLL FVFPHLTKSA DVKFKIRTVV DSLVKPTSVS VFENGDIYVA
     EESVVSKIYT NGTKVIVAGG GSDTSSAVMV PTQAQLNIYF SSFDCIGKPG AYGSASSGTY
     FLKNLSSPKG IFRTSKNEFY IAESSGRVKV YNGTLRQIAG VGLIGSSCPD DSDALTCLIS
     NTNGIFVSGK NEVYITEMIA SGTVRKLYPY CEDGLVLSSD GRLCNPLCFT KSGNEACGGP
     SHGLCIDVDT CQCNNNYYGM ACELPKCFGK NSTLYCSMNG ECIDVNNCSC NSNYYGIECN
     VTTCDGKFSN NSNTCSNHGT CVDYNICECN ENYEGTFCNI SKCNGTLSND PSVCSGNGNC
     LEYDTCQCFN SSMYSGSFCE IPICFGILAN QSLSVCSGQG NCISVDQCQC NSKYGGSQCE
     IPFCNTKLGT DPLVCNSHGN CTAPNQCQCM SGYDGSECEL INCFGIYSNQ TNQICNQGNG
     TCLAPDTCSC NSGWTGLNCE IPICHGVPSN NSRACSSNGQ CTNPNYCKCD SNYYGTNCEK
     TTCNSVPSDD SNVCFGNGKC ISYNNCNCSD GYGPSTTCQF PICFGKLAND SSVCNDTEQY
     CDAPNECKLK NPICFGIEKL DNRSCSGNGK CLSTDYCKCD FNYFGEECQY FKCNGVEFNS
     TRVCNSHGVC KFLNTCICEN GFGGNNCELV ECNGILESSS SVCSGRGTCL NVDQCECEYG
     YSGSNCQFTS CFGIEQESSQ VCNLGNGTCR SFDYCKCVNE SKWFGPQCNI TYCYGETSVD
     SKVCSSQGDC VNYDTCHCKK DFIGNKCQFK FLSQAMKLSF NNTSDIVGDI STIISLSIQD
     SSFLDYYVNQ SINIFIEFLL DGQFDSSSTV HQQLTSSIPF NLPASLSKTG SLTAKAALSL
     NSTLISFRVE TETALSLQLK NIPQISARLT SLPFLAIDSV HSENTGVIVA AVVVPIVSVA
     VIGGGVAVLI TTIVIMMKKK ASASLAKDLI MAGATDVELA
//