ID D2VSN5_NAEGR Unreviewed; 356 AA.
AC D2VSN5;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Set domain-containing protein {ECO:0000313|EMBL:EFC40221.1};
GN ORFNames=NAEGRDRAFT_72003 {ECO:0000313|EMBL:EFC40221.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC40221.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC40221.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR EMBL; GG738894; EFC40221.1; -; Genomic_DNA.
DR RefSeq; XP_002672965.1; XM_002672919.1.
DR AlphaFoldDB; D2VSN5; -.
DR STRING; 5762.D2VSN5; -.
DR EnsemblProtists; EFC40221; EFC40221; NAEGRDRAFT_72003.
DR GeneID; 8857018; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_72003; -.
DR eggNOG; KOG1082; Eukaryota.
DR InParanoid; D2VSN5; -.
DR OrthoDB; 5481936at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd10531; SET_SETD2-like; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46223:SF3; HISTONE H3 (LYS9) METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR46223; HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..356
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003038367"
FT DOMAIN 184..319
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 335..351
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
SQ SEQUENCE 356 AA; 41382 MW; EB5B5DE5B6B5245E CRC64;
MKQFSSTLLI LFFSQYCEAF VLYNCARVCS RWRKIIHNRV DISLGKEDLK IVNYSNHDEI
LLNDFTYIIE NYWSEDIIGD DFQLLDEENE DNKNDELTNS VCDCNKLISS HSNIVVRKIS
CSTMDCSCFA RNYHNGKHFL KPENGLLDLD YSFPIIECSD DCSCDSTRCR NRITPIHYLG
TIDKPLYLFS IGECVGFGVK CKNFIQKGEF ISEYIGKVLS DKESNEILNS SIQDKHHYLL
IIKEYFHISQ ALESKQKYET RRLNIDAEKF GNVSRFFNHS CDPNLTWRVL RTCSEDHPRL
FFFAAKDIPE NTELTFDYGE GNTLQNNESA NLQFSQRKCQ CKSQNCKGFL PLVSIK
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