ID D2VT32_NAEGR Unreviewed; 343 AA.
AC D2VT32;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2-like protein {ECO:0000313|EMBL:EFC40013.1};
GN ORFNames=NAEGRDRAFT_83266 {ECO:0000313|EMBL:EFC40013.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC40013.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC40013.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738895; EFC40013.1; -; Genomic_DNA.
DR RefSeq; XP_002672757.1; XM_002672711.1.
DR AlphaFoldDB; D2VT32; -.
DR STRING; 5762.D2VT32; -.
DR EnsemblProtists; EFC40013; EFC40013; NAEGRDRAFT_83266.
DR GeneID; 8854233; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_83266; -.
DR eggNOG; KOG2987; Eukaryota.
DR InParanoid; D2VT32; -.
DR OMA; FEWVYND; -.
DR OrthoDB; 5485164at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR013866; Sphingolipid_d4-desaturase_N.
DR PANTHER; PTHR12879; SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2; 1.
DR PANTHER; PTHR12879:SF8; SPHINGOLIPID DELTA(4)-DESATURASE DES1; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR Pfam; PF08557; Lipid_DES; 1.
DR SMART; SM01269; Lipid_DES; 1.
PE 4: Predicted;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..55
FT /note="Sphingolipid delta4-desaturase N-terminal"
FT /evidence="ECO:0000259|SMART:SM01269"
SQ SEQUENCE 343 AA; 40081 MW; 092A31E133C45B8D CRC64;
MAPTKENNWA GVDPSLLNQK DYLWTKTDEP HWNRKKELLK KYPQIKELYS IDPMTKWKIL
LLVLIQFATC YYVVTAKPAW YIVLACMWVI GGTCNTSLTV GIHELTHGVG FETLEYNYMM
AIFGNLPLAV PFAMSFKRYH HEHHVYQGVL GLDTDIGTPI EAKFFNTRYT KFLHVLFMVF
FYALRPLFLL PKIPNKWELI NQAVIFSFVG VVTYFFGWMS IIYFLGSDFF GLGLHPLAGH
FISEHFVTRP GQETYSYYGI GNLFMFNVGY HNEHHDFPKI PGCNLPKLKE IAPEYYNNLK
VTESWTYALW EYITTDGYTP FNRVARTHED HKNARKNDSK KDQ
//
