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Database: UniProt
Entry: D2VT68_NAEGR
LinkDB: D2VT68_NAEGR
Original site: D2VT68_NAEGR 
ID   D2VT68_NAEGR            Unreviewed;       477 AA.
AC   D2VT68;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=Carboxypeptidase Q {ECO:0000256|ARBA:ARBA00014116};
DE   AltName: Full=Plasma glutamate carboxypeptidase {ECO:0000256|ARBA:ARBA00033328};
GN   ORFNames=NAEGRDRAFT_52057 {ECO:0000313|EMBL:EFC40031.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC40031.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC40031.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- SUBUNIT: Homodimer. The monomeric form is inactive while the homodimer
CC       is active. {ECO:0000256|ARBA:ARBA00025833}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus
CC       {ECO:0000256|ARBA:ARBA00004555}. Lysosome
CC       {ECO:0000256|ARBA:ARBA00004371}.
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DR   EMBL; GG738895; EFC40031.1; -; Genomic_DNA.
DR   AlphaFoldDB; D2VT68; -.
DR   STRING; 5762.D2VT68; -.
DR   EnsemblProtists; EFC40031; EFC40031; NAEGRDRAFT_52057.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_52057; -.
DR   eggNOG; KOG2195; Eukaryota.
DR   InParanoid; D2VT68; -.
DR   OMA; LFMNEEN; -.
DR   OrthoDB; 2785567at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0070573; F:metallodipeptidase activity; IEA:InterPro.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR039866; CPQ.
DR   InterPro; IPR007484; Peptidase_M28.
DR   PANTHER; PTHR12053:SF3; CARBOXYPEPTIDASE Q; 1.
DR   PANTHER; PTHR12053; PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   4: Predicted;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022645};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Protease {ECO:0000256|ARBA:ARBA00022645};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..477
FT                   /note="Carboxypeptidase Q"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003037848"
FT   DOMAIN          276..460
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
SQ   SEQUENCE   477 AA;  52960 MW;  AB0925229CD5B034 CRC64;
     MSRQLLSSGG LLIGVVLFVA TMLQSFTTDQ YHHSMVEATK ISTNAFPNNY KEKVDQICQH
     IIKGEEKGKL YDLLAFLTDT YGSRLVGTEG FDLTCKHFAK LMQANGFDNV HTEPVYNITH
     WRRGEPESLI MHEPRYIPRM EVLALGTSPP GSVKSEVIVL KSYEELDQYD VRGKIVLFNL
     PWQGTYGKSV IFRTRGPAEA AKRGAAACLV RSVTPFSIYS AHTGGTNFQD DEKRIPAATI
     TVEDADMIER MIKRGQRVVL SLKLNCENLP PLTSYNTLGE ITGSTYPNEV IVVGGHMDSW
     DLNSCPMDDI GGILTFYEGM KTLIKLGLRP KRTIRLEEFG GGRFGGMSYV KEHEKELKDH
     ILAIESDAGP FKPLGFEFTG GEEGRKLVEL IASTLFTNIN TTQVTDNGGG ADVDPLYQVA
     GIPVMSPKVE GSKYFWFHHS KADTMTVLNT DDLDLAAAQM GAFLYVVADM DVRFPRN
//
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