ID D2VT68_NAEGR Unreviewed; 477 AA.
AC D2VT68;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Carboxypeptidase Q {ECO:0000256|ARBA:ARBA00014116};
DE AltName: Full=Plasma glutamate carboxypeptidase {ECO:0000256|ARBA:ARBA00033328};
GN ORFNames=NAEGRDRAFT_52057 {ECO:0000313|EMBL:EFC40031.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC40031.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC40031.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBUNIT: Homodimer. The monomeric form is inactive while the homodimer
CC is active. {ECO:0000256|ARBA:ARBA00025833}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG738895; EFC40031.1; -; Genomic_DNA.
DR AlphaFoldDB; D2VT68; -.
DR STRING; 5762.D2VT68; -.
DR EnsemblProtists; EFC40031; EFC40031; NAEGRDRAFT_52057.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_52057; -.
DR eggNOG; KOG2195; Eukaryota.
DR InParanoid; D2VT68; -.
DR OMA; LFMNEEN; -.
DR OrthoDB; 2785567at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0070573; F:metallodipeptidase activity; IEA:InterPro.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR039866; CPQ.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12053:SF3; CARBOXYPEPTIDASE Q; 1.
DR PANTHER; PTHR12053; PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022645};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022645};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..477
FT /note="Carboxypeptidase Q"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003037848"
FT DOMAIN 276..460
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 477 AA; 52960 MW; AB0925229CD5B034 CRC64;
MSRQLLSSGG LLIGVVLFVA TMLQSFTTDQ YHHSMVEATK ISTNAFPNNY KEKVDQICQH
IIKGEEKGKL YDLLAFLTDT YGSRLVGTEG FDLTCKHFAK LMQANGFDNV HTEPVYNITH
WRRGEPESLI MHEPRYIPRM EVLALGTSPP GSVKSEVIVL KSYEELDQYD VRGKIVLFNL
PWQGTYGKSV IFRTRGPAEA AKRGAAACLV RSVTPFSIYS AHTGGTNFQD DEKRIPAATI
TVEDADMIER MIKRGQRVVL SLKLNCENLP PLTSYNTLGE ITGSTYPNEV IVVGGHMDSW
DLNSCPMDDI GGILTFYEGM KTLIKLGLRP KRTIRLEEFG GGRFGGMSYV KEHEKELKDH
ILAIESDAGP FKPLGFEFTG GEEGRKLVEL IASTLFTNIN TTQVTDNGGG ADVDPLYQVA
GIPVMSPKVE GSKYFWFHHS KADTMTVLNT DDLDLAAAQM GAFLYVVADM DVRFPRN
//