ID D2VTJ2_NAEGR Unreviewed; 376 AA.
AC D2VTJ2;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=Ran family small GTPase {ECO:0000313|EMBL:EFC39869.1};
GN ORFNames=NAEGRDRAFT_72321 {ECO:0000313|EMBL:EFC39869.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC39869.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC39869.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC {ECO:0000256|ARBA:ARBA00008028}.
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DR EMBL; GG738896; EFC39869.1; -; Genomic_DNA.
DR AlphaFoldDB; D2VTJ2; -.
DR STRING; 5762.D2VTJ2; -.
DR EnsemblProtists; EFC39869; EFC39869; NAEGRDRAFT_72321.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_72321; -.
DR eggNOG; KOG0096; Eukaryota.
DR InParanoid; D2VTJ2; -.
DR OMA; SETHTHM; -.
DR OrthoDB; 5472510at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR CDD; cd09917; F-box_SF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002041; Ran_GTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR24071:SF0; GTP-BINDING NUCLEAR PROTEIN RAN; 1.
DR PANTHER; PTHR24071; RAN GTPASE; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT REGION 109..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 43470 MW; C6063BE7E8694E58 CRC64;
MELLEESCLL SVINLPKEIW LYQICEYLDI LDMIFSLGRV CKAFRYELAN EYLKKFPKTK
KKDSNDQVSS IDSFSMRRVK YIIRDELLKF IVKFEKSLTN EGIFEKKDTS HVSEQSNAQQ
NDPKSTNGGP TIEKERLMEL FQSRMEIFDF YFSHFYKKLP SDASESAIKQ TSIASSLFKS
ENQLVESSSA RNTEMKKILI IGNGGVGKTT FCRSMQDLPL NDNRNLPTIG CEINSYRLKI
AGLEANINLW DTVGQEKFGF LRDTLYVNTS VCIICFDLTS RYSYKSILNW FRDIKRVEPE
CEVIFVGTKL DLTDNLKVTP KQITFPINKY CPYIGLSSLQ QINNRAVLWY VAFMNLFVSH
LKGIHETLIC DKETIN
//