ID D2VU27_NAEGR Unreviewed; 430 AA.
AC D2VU27;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC39555.1};
GN ORFNames=NAEGRDRAFT_72514 {ECO:0000313|EMBL:EFC39555.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC39555.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC39555.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; GG738898; EFC39555.1; -; Genomic_DNA.
DR RefSeq; XP_002672299.1; XM_002672253.1.
DR AlphaFoldDB; D2VU27; -.
DR STRING; 5762.D2VU27; -.
DR EnsemblProtists; EFC39555; EFC39555; NAEGRDRAFT_72514.
DR GeneID; 8855784; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_72514; -.
DR eggNOG; KOG1225; Eukaryota.
DR InParanoid; D2VU27; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF69; TENEURIN-M; 1.
DR Pfam; PF01436; NHL; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 227..262
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
SQ SEQUENCE 430 AA; 46746 MW; 84C6F6FDE3398004 CRC64;
MAQSSLNGDV YFATTVVSSV RRINTNNLIT TIAGNNQIAY SGDGGLAIAA SFRIPYGVAL
GMNGELFITD TNNNVIRKVS STIGIITTIA GSVTGGYSGD GGLAIAAKLS SPYGIVVDQL
NGTIYVCDFG NSRVRKLVPY CTKGTLVNGN CVYPVCYDLD FDDVRVCSGH GNCQSSNHCN
CQEGWNGSLN CSIFSCESIG NCNGNGKCIS NNTCECQSGW NSTFDCSQFE CNDLNNCNGN
GQCISNSTCE CQSGWRGNSQ CSATSCDALS QCNGNGKCIS NNTYTPGQEE LRPLSYDKPS
KCHIFIMCYA ISSPVMMIKC LEDFSDRFLP EIQSFLDYNR SVLVVGTKSD ICDYSKTGDF
RLGKYWNSYL CKKYDSYGKK LSQWMGAVSY VTTSSREFVG LEELEDLIVK TFIYSKLIKA
PNKKEKCILC
//
